ARINA-1 Clinical Trial with nebulized solution-NO ANTIBIOTICS

Posted by becleartoday @becleartoday, Aug 17, 2023

GOOD NEWS!!!

We have been asking for bronchiectasis treatments that are not antibiotics, and we have been heard!

Dr. Charles Daley is a well-respected expert from National Jewish Health in Denver. He was a keynote speaker at the World Bronchiectasis Conference and gave the closing remarks.

Dr. Daley is also the principal investigator of a study evaluating ARINA-1, a nebulized solution manufactured by Renovion that has been shown to prevent mucus from clogging our airways. Clogged airways cause inflammation and infection, a cycle we try to break with daily airway clearance and, often, antibiotics.

ARINA-1 is a sterile formulation that is manufactured under strict guidelines. The solution includes glutathione, ascorbic acid, and a buffer to modify the pH.

The trial will measure ARINA-1’s impact on quality of life, mucus viscosity, and inflammation.

Researchers are looking for 25 more participants for the 28-day study. Participants need to be diagnosed with non-CF bronchiectasis and have mucus. In addition to National Jewish in Denver, trial sites are located in Baltimore; Philadelphia; Seattle; Birmingham, AL; New Orleans; Tyler, TX; Winston-Salem, NC; Portland, OR; and Charleston, SC. If you live in or around one of these areas and are interested in the trial, let me know.

Click on the following link to clinicaltrials.gov for more information on the ARINA-1 trial.
https://tinyurl.com/tsh6fjnr
I am working with Renovion and researchers to share this opportunity, and I can help answer basic questions regarding:

-Participating doctors
-Laboratory studies of ARINA-1
-How nebulizing this solution differs from nebulizing glutathione alone or orally administered NAC
-The importance of the combination of glutathione and ascorbic acid

If you have other questions about the trial, the drug or how to enroll, let me know and I can help you get an answer from the Chief Scientific Officer at Renovion who is a great resource.

Most importantly, discuss this trial with your doctor.

Dr. Daley implored us to get involved in bronchiectasis and NTM research. Let’s show him and the researchers working on our behalf that we are willing to participate whenever possible.

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

raney | @raney | May 18 6:40am

I am interested in the 3rd trial. I can go to Charleston SC or to
Winston Salem NC.. Thank you for sharing.

becleartoday | @becleartoday | May 18 8:17am

I hear you! There’s nothing in place yet. They’re still looking for funding.

jerjer | @jerjer | May 19 2:29pm

Good Afternoon, I’m very interested in the trial. I am a patient of Dr Haas an associate of Dr Daley’s at NJH. I meet the criteria and would like to participate in the trial. Thanks!

becleartoday | @becleartoday | May 19 3:25pm

Phase 3 trials won’t get started until next year.

ccdb | @ccdb | May 20 11:20am

In reply to @becleartoday "Phase 3 trials won’t get started until next year." + (show)

Linda,

I live in the Winston-Salem, N.C. area. All of my doctors are in Winston-Salem. I would be happy to participate in the Clinical Trial Study. Do I need a letter or other documentation from my ID doctor and/or my Pulmonologist?

Please let me what I need to do to volunteer for the Clinical Trail.

Thank you.

Cathie

busybeans | @busybeans | May 20 11:30am

I meet the criteria and am a patient of Dr. Daley's. Next steps?
Thanks!

becleartoday | @becleartoday | May 20 1:22pm

In reply to @ccdb "Linda, I live in the Winston-Salem, N.C. area. All of my doctors are in Winston-Salem. I..." + (show)

They are not currently up and running. When they are, I’ll be sure to post. It probably won’t be until next year.

becleartoday | @becleartoday | May 20 1:23pm

In reply to @busybeans "I meet the criteria and am a patient of Dr. Daley's. Next steps? Thanks!" + (show)

Dr. Daly will tell you it is not up and running yet. We have to be patient… Unfortunately!💕

ccdb | @ccdb | May 20 4:48pm

In reply to @becleartoday "They are not currently up and running. When they are, I’ll be sure to post. It..." + (show)

Linda,

Thank you. I have an appointment with my ID doctor next week, and my Pulmonologist at the end of the month. I will mention to them as well. I know my ID doctor knows about the new therapy because he mentioned it to me last week. I will ask my Pulmonologist, but I doubt she does. (A sad statement, I know)

Thanks again.

Take care and be safe.

Cathie

scoop | @scoop | May 20 8:03pm

With all the discussion around Arina-1 I wonder if any persons on this forum participated in the previous trial. It'd be excellent to hear from anyone who participated. Maybe they are not allowed to talk about it, I don't know.

The closest trial to me was plane ride away. After I inquired they wrote to me a week later and said they would reimburse all my travel expenses. There were 3 visits involved. I ruled it out before finding out more info. Honestly, I wasn't too enamored to sign up for more blood tests, spirometry or possibly CT scans --not that those were included but in my imagination they might have been!