Anyone in this group been on Tagrisso and have it stop working?

He thought Tagrisso would shrink it. He did not want to do surgery. The last visit when the ct showed growth he did say based on biopsy results we might consider radiation or chemotherapy while still taking Tagrisso. At the moment that is the only tumor I have. I had the brain tumor surgically removed and had 3 radiation treatments.

If you’re on Facebook, you can find groups with further discussion of these topics, e.g., “Tagrisso,” “LUNGevity,” and “EGFR Resisters,” to name a few.

Agree with the above. You can get a lot of information on osi "resistance" and recurrence from the EGFR Resisters group. And info/support questions like yours get a lot of responses on their facebook page. Just be concious that responders will have different stages, pre and post treatments, EGFR mutation variants, etc.

I’ve been on Tagrisso just three weeks and I find it very strong and I don’t like how it makes me feel…I’m on the 80Mg recommended dosage. I can’t find any info on the efficacy of the 40mg tablet….I have stage 1b and had a lobectomy no cancer at this time. I appreciate all of the comments…Stay strong

Need info on 40 mg Tagrisso

@mollie2 If you're experiencing discomfort after 3 weeks, I strongly recommend telling your Oncologist how you're feeling first thing tomorrow morning. Doctors know that every body is different and can usually offer alternatives or, depending on what your discomfort is, offer treatment options for the symptoms. Diarrhea is common, and Imodium worked for me and others. I was up to 2/day for a while. But that's me. See what your doctor thinks.

All the best to you. Tagrisso has been something of a wonder drug since it was introduced in 2017.

Stage4 lung cancerI'm 67 ,female

Tagrisso

Welcome to Mayo Connect @duan62533732. I’m sorry to hear that you are facing recurrence of your cancer. There are others here that have been diagnosed with EGFR lung cancer. I have a different mutation, ALK (stage IV). It’s a scary position to be in, we all know that someday our targeted therapies will no longer be effective, and it leaves us in an uneasy position.
Has the progression been to your lungs, or another area? Is your team able to get a new biopsy for additional testing?

A scan few days ago revealed a new tumor in the upper left lung, because of neck pain, there may be bone metastasis and brain metastasis. The doctor will arrange for an MRI and another genetic, then decide on a medical plan.
I'm just frustrated. Thank you for replying me.