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Not eligible for Immunotherapy. Now what?

Lung Cancer | Last Active: May 22 5:00pm | Replies (58)

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@dougmck

I'm experiencing this situation now. I also have multiple lung nodules in both lungs after being in remission from Stage 3-B treatment in 2008 for ten years, beginning in 2018 when they begun becoming malignant. Besides the radiation I experienced for the primary cancer in 2008, I've had four different nodules radiated since 2018 and my radiologist and oncologist are telling me we're running out of treatments. The radiologists who read my CT's continue to report that I have multiple other nodules in both lungs that appear to be growing in size. I also don't have biomarkers, but my oncologist at UCSF is considering Keytruda, based on a current trial (IMPRINT) at M.D. Anderson. He has warned me, however, that his patients who have undergone lung radiation are at a higher risk for pneumonitis when on the immunotherapy drug. I'm curious if anyone who has had radiation for slow-growing lung nodules have had experience with Keytruda.

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Replies to "I'm experiencing this situation now. I also have multiple lung nodules in both lungs after being..."

@dougmck, I think @abingham84's mom may have had radiation and Keytruda. You might also be interested in this related discussion:

- Keytruda for NSCLC: What's your experience?
https://connect.mayoclinic.org/discussion/keytruda-2/

I had SBRT (3 sessions) last August for lung nodules and two months later had an episode of pneumonitis. They put me on Prednisone for 59 days which took care of it. I was told also that because of the episode I could no longer have immunotherapy because of risk. I have multifocal lung cancer (independent primary slow growing cancerous nodules in the lung).
I also have pre-existing pulmonary fibrosis which was stable. My pulmonary function tests dropped considerably recently so I will start an anti-fibrotic drug which hopefully will slow down the progression of the fibrosis. I found a research article that antifibrotic drug may help reduce side effects of cancer treatment as well (attached) ...ask your Oncologist

Shared files

Lung cancer in patients with fibrosis 2022 (Lung-cancer-in-patients-with-fibrosis-2022.pdf)