Timing of Reclast Infusion after your last Evenity Injection.

Thanks for the CTX idea —by the way…what is it? Does everyone need this test or only those with kidney problems?

Hi @rhondat23 - I would get your Reclast infusion right after your Evenity treatment (30 days after your last Evenity shot). It's not as critical as stopping Prolia, but BMD values drop pretty quickly after treatment and CTX rises quickly as well. Attached are two charts showing the effects of stopping Evenity (romosozumab) without follow-on treatment. I highlighted the curves of interest. You can find the study by Dr. Michael McClung here https://doi.org/10.1002/jbmr.3452 .

@michaellavacot there seems to be a difference of opinion on this. Some docs are saying a month after, and some are saying 2-3 months. I don't think anyone knows. CTX tests are probably the best bet for guiding the transition but even that is imperfect.

@windyshores - Just to be on the safe side, I would do it immediately. From the trial data I posted, you can see CTX goes to ~80% above the baseline in just 3 months, which can be very high for a lot of people. The curve actually resembles Prolia's rebound CTX curve with similar BMD percentage losses by one year.

@michaellavacot this is a matter of confusion among doctors. My doctor is "world class" at a major teaching hospital where a lot of research is done, and he says there is no rush, that Evenity mineralization takes a couple of months or so.

Also, I need to heal from my side effects on Evenity before presumably taking on more side effects with Reclast. I have done 5 years cancer meds, two years Tymlos, 4 months Evenity and my body is tired.

McCormick also says to wait, based on the CTX. Mine is quite low and he says Reclast won't be effective.

I will look at the trial date if you could repost it where I can see it.

@michaellavacot this is a matter of confusion among doctors. My doctor is "world class" at a major teaching hospital where a lot of research is done, and he says there is no rush, that Evenity mineralization takes a couple of months or so.

Also, I need to heal from my side effects on Evenity before presumably taking on more side effects with Reclast. I have done 5 years cancer meds, two years Tymlos, 4 months Evenity and my body is tired.

McCormick also says to wait, based on the CTX. Mine is quite low and he says Reclast won't be effective.

I will look at the trial date if you could repost it where I can see it.

Did you notice that there is minimal to no difference between full Evenity dose and roughly half dosage?

@normahorn what were you referring to, that has no difference between full and half dose for Evenity?