@allig
Following are links to previous conversations and recommendations. But, once you narrow down the choices, I suggest you contact hotel directly and ask if any conventions / groups are staying at hotel at same time. Last thing you want to be is at a hotel where large youth group is staying. Rochester often is host to sports tournaments or conventions in spring and summer. Most time they are on weekends.

A good place to start is contacting Concierge Services at Mayo Clinic. They can make recommendations specific to your needs.
https://www.mayoclinic.org/patient-visitor-guide/minnesota/concierge-services

Here are previous recommendation people have shared in these related discussions (there are so many):
- Looking For A Hotel Suggestion
https://connect.mayoclinic.org/discussion/looking-for-a-hotel-suggestion/
- Closest / best hotel for one night stay
https://connect.mayoclinic.org/discussion/closest-best-hotel-for-one-night-stay/
- Rochester Hotel rooms/kitchenette/grocery suggestions
https://connect.mayoclinic.org/discussion/rochester-hotel-roomskitchenettegrocery-suggestions/
- Rochester hotel with suites, good gym, and free breakfast/wifi
https://connect.mayoclinic.org/discussion/rochester-hotel-with-suites-good-gym-and-free-breakfastwifi/
- Mayo Clinic Rochester MN: Where to Stay? Shuttles? Parking?
https://connect.mayoclinic.org/discussion/where-to-stay-1st-visit/

When do you plan on visiting?