I had two trials, first with morphine, the second with hydromorphone. Only the hydromorphone took my pain from an 8 down to a 2. That's what made me decide to have the permanent implant done. I had a few days of good pain relief after about a month and a half after the implant. Then, nothing. We moved to a new state and now have a new pain doc managing the pump. After several adjustments with no effect, he suggested refilling the pump with a mix of hydromorphone and an anesthetic. That was worse than the plain hydomorphone, so it was removed and the original hydromorphone put back in. My understanding is that there are only three drugs approved for pain pumps: morphine, hydromorphone, and fentanyl. Not sure I want to go down the fentanyl route.