Prolia and Evenity Together

Thanks so much for posting this link..I like to use PubMed too! I also heard that Fosamax was an option too…my docs don’t say much about options but I did say I’d like to avoid as many side effects as possible…like you say they all do…but choosing the least is what I can do…it’s scary as I haven’t used meds much at all. Thanks.. I’m falling down on my research.

The 9th month.

Clearly you understand my response, because that's were you double down.
A readers perspective is not the same as a writer's perspective. Eat all the reader's salt you can take, but don't lasso together disparate, deeply felt experiences and throw salt at all of them. These members deserve of deep respect.

I really like , the Dr. Doug Show on YouTube . He states studies . Look for the one on ; Can you stop Prolia ? Or will it increase fracture risk ?

Ok thanks for taking the time to tell me this…and others that may be interested too!

After re-reading my initial response to our thread and follow-on responses, I can see I choose some words poorly and even discounted member experiences. That was wrong. The member feedback is very valuable and new users looking to gain knowledge should learn from their experiences.

The point I was and am trying to make (this is where I push all in) is that osteoporosis medication adverse events are rare. When reading posts on this and others forums, that likely have significantly more postings of people experiencing problems than not, could give you the impression that there is a high likelihood of having an adverse event. My response was addressing the members comment “Prolia and Reclast have so much bad press…don’t know what to take”. In actuality, both Prolia and Reclast have very few adverse events in both trials and real world treatments as compared to the number of people taking the drug. I’m not saying you won’t have an adverse event, but that they are rare.

During the World Congress of Osteoporosis that happen last weekend, Dr. Serge Ferrari discussed the adverse events over the 10 years of the Denosumab (Prolia) Freedom trial. I will create a separate posting with the findings for both atypical fractures and osteonecrosis of the jaw.

Again, sorry that we are not connecting on this one. Mike

I believe you are doing everyone a disservice by claiming that adverse reactions are '"Rare". Personally I want the facts so I can separate what is within the realm of expectation from what is excessive.

This was provided to me by the office of one specialist regarding Evenity. I consider all of these far outside the classification as "rare".

Adverse Reactions

>10%:
Neuromuscular & skeletal: Arthralgia (8% to 13%)

1% to 10%:
Cardiovascular: Cardiac disorder (2%), peripheral edema (2%)
Central nervous system: Headache (5% to 7%), insomnia (2%), paresthesia (1%)
Dermatologic: Skin rash (1%)
Hypersensitivity: Hypersensitivity reaction (7%)
Local: Injection site reaction (5%), pain at injection site (2%), erythema at injection site (1%)
Neuromuscular & skeletal: Muscle spasm (3% to 5%), asthenia (3%), neck pain (2%)

You really need to compare the number of adverse events on drug to placebo to see the net effect from the drug. Attached is the table from the Evenity package insert as well as the section on MACE events.

You can find the insert here https://www.pi.amgen.com/-/media/Project/Amgen/Repository/pi-amgen-com/Evenity/evenity_pi_hcp_english.pdf

Don't forget about the adverse events of not taking this or other osteoporosis drugs. A broken hip or spine are pretty bad adverse events.

I agree that adverse affects are not the normal response but I strongly disagree with your use of the term "rare". One in a hundred would qualify as uncommon; one in a thousand might be considered rare. I am a firm believer in informed consent and that is not possible when people sugarcoat the reality. Medical practitioners do that enough; we do not need to belittle the agony of those who suffer from the adverse effects,

There is one fallacy in comparing the effects to those of a placebo; intensity of reaction is not included. A placebo might give someone a minor headache but the medication might send them to an ER for a throbbing headache. Both might be counted simply as a headache.

We can not and should not dismiss the reality of those who suffer disabling consequences.

And it is important to know what might occur even if most people do not experience it. Knowing I might experience light-headness may mean I should not engage in any activity where falling could have serious consequences.

BTW, I have a true rare reaction to vitamin B-12. It is water soluble and any excess is supposedly excreted through urine. Someone forgot to inform my body of that and it holds on to the B-12. I went from being deficient to the value being off scale with a daily supplement. MY PCP had wanted me on weekly injections.

njhornung,
selection bias in inherent in clinical trials not reflective of the population at large.
As you elucidated in an earlier comment, post market canvasing is even less reflective as prescribing norms preclude vulnerable patients.
We know how to read clinical trials. We know about the placebo column. None of us forget the risk of fracture.
The value of this site is in the telling of our real life experiences among friends who honor and appreciate us.