Loss of BMD in hips after taking Forteo or teriparatide?

I just wanted to boost my femur neck and also "treat to target," meaning get all the scores as close to osteopenia as possible. I attended a masterclass offered by Lani Simpson, back in 2021, where a woman described her gains on Tymlos and her gains on Evenity after Tymlos. I didn't even realize that was not a protocol prescribed by my endos until I requested it. For now, in both practices I go to, I am the only patient doing this. My idea was to do just 3-4 months for a boost, then Reclast. I have since seen studies investigating that kind of use of Evenity, and hope it becomes mainstream in the future. For now, I am my own guinea pig- and my doctors'!

Today I read that femur neck only progresses 2.8% in the first 6 months and 7.5% if Evenity is done for the full 12 months. Surely this is from anti-resorptive action but the gain is much stronger than with Reclast (though values are extremely varied for Reclast among studies). So the idea of a boost over 3-4 months may mainly apply to the spine. Nevertheless studies are being done on Evenity for 6 months and Reclast for 6 months vs Evenity for 12 (followed by 12 months Reclast).

I saw 1) 6 months Evenity, 12 months Reclast, 6 months Evenity. 2) 6 months of each 3) 6 months Evenity, 12 months Reclast, 4) 12 months of each and 5) 6 months Evenity, 18 months on Reclast

@mayblin You might want to check this one out.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190496/ "The Effect of Teriparatide on the Hip: A Literature Review"
This paper which is mainly summarizing the effects of Forteo on those who have not previously been treated with anti-resorptives is quite positive for Forteo and it's effects on the hips. It has an understandable section covering how one could lose cortical bone in the hip and still become more fracture resistant. Perhaps the negative comments about Forteo and the hips are mainly from studies where an anti-resorptive is followed by Forteo, which seems to cause significant hip bone loss? I intend to read more on this but I've no time for that right now. Hopefully this paper and others like it will help us understand this issue better.

Why do you consider Forteo to be safer than Tymlos and what do you like after Forteo? Are we all destined to eventually have risks from busphisphrnates? Hrt supposedly may also holds after Forteo or Tymlos.

All I know personally is that Forteo was way too potent for me and I could tolerate Tymlos, though as you know I worked up to it 🙂

Windy

Please tell me the procedure for gradually taking Tymlos.

CC

@06111945cc The Tymos pen as 8 clicks for a full dose. You can feel the clicks. You can start at a full dose and if you have any issues, go back to 2 or 4, whatever you can tolerate. Once your body adjusts, move up. You want to aim for 6 or 7 clicks at least out of 8. Talk to your doctor about this of course. If you refrigerate it, the Tymlos pen can last longer so the reduced dose doesn't mean you have to throw it out at 30 days. I checked this with the company.

@gently. My endocrinologist said the Forteo dose is not too high for me (I’m 5’2” and weigh 120 lbs). She said they give it to children. I’m about to start, so it will be interesting to see how my body reacts.

Not so sure about the children. It isn't recommeded for children whose bones are still growing. It is given to kids with hypocalcemia. But the dosage is titrated by weight. And given more frequently by infusion.