Amen to that @susan2018! I quickly learned as my restless legs progressed that alcohol not only started them, but it worsened through the night. You mention wine, but for me, it is any kind of alcohol. It used to be that I couldn't drink any after 6:00, and over the past years, the time has become earlier and earlier so that now, if I drink alcohol at all, it can only be one beer or one glass of wine before 3:00 p.m. I do miss the occasional glass of wine at dinner, but the after-effects are not worth it. The same is true with any product containing caffeine - chocolate, Bufferin, or coffee. As for SSRIs, they worsened my symptoms as do Ativan, Compazine, Klonapin, etc. My Sleep Center doctor suggested I use only Wellbutrin for treatment of depression since studies have shown that SSRIs especially aggravate restless legs. So, you are right about the SSRIs too . . . I was taking Celexa and when I switched to Wellbutrin, it worked even better for me than Celexa.