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WBC count keeps getting lower and lower

Blood Cancers & Disorders | Last Active: Feb 12 12:33pm | Replies (18)

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@thipley

I had the same thing happen to me. I was being dismissed until I pointed out that my WBC count had been dropping steadily over a year’s span. I was then referred to a hematologist who performed a bone marrow biopsy with Next-Generation Sequencing (NGS).. It was determined that I have clonal cytopenias of undetermined significance (CCUS) with a low level mutation in the KMT2C gene. My hematologist wants to see me every 6 months, and I’m in a watch and wait scenario. It could turn into something down the road. My main goal is to reduce the inflammation in my body by exercise and eating better. My WBC has never gotten as low as your 2.1, so I think a referral to a hematologist is the right direction for you. Also, besides my absolute neutrophils, glucose, A1C, and cholesterol, my other bloodwork looks fine.

Per my hematologist, “ This condition may never develop into a blood disease but does increase the risk of a pulmonary disease known as myelodysplastic syndrome. Therefore, it should be monitored periodically to ensure there is no progression of the low white blood cell count and/or the development of additional abnormalities.”

More info on CCUS:
https://blog.dana-farber.org/insight/2019/04/what-is-clonal-cytopenia-of-undetermined-significance-ccus/

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Replies to "I had the same thing happen to me. I was being dismissed until I pointed out..."

Thank you for your reply.
I have an appointment booked soon, so my WBC will be tested once again and we will see from there. My doctor mentioned that maybe this low WBC count is a consequence of some past infection, but then again, the drop has been pretty steady over the course of months, which is the thing that worries the most.

I will try not to panic and just follow my doctor's advice

Best wishes to you!