I don't sleep well and avoid taking in the evening, just in case I have any stomach issues. I take each morning with my breakfast, drink lots of water ( to help flush the toxins ) and avoid long term exposure to the sun. I take the same dosage as you do and do not have any side effects from this medication. Most of the side effects mentioned in these posts can be attributed to the aging process...dry itchy skin, bruising, fatigue, hair loss, etc. The aspirin we all probably take with our hydrea is more likely to cause stomach upset. I take coated aspirin with my meals as well. I have experienced no side effects at all in the last three years. I am 66 years old.