I am sorry you are having these issues with Prolia. Perhaps a consult with another physician might be beneficial. If you are being treated by an endocrinologist, maybe try a rheumatologist? Or the other way around. It's been my experience that going to a different hospital system, preferably in a different city results in a better second opinion. Only you know how your body reacts to certain medications. While the majority of people in a study might have positive results with a medication, there often are a number of people who have negative reactions. But they do. And they shouldn't be disregarded. If you think your symptoms are the result of this medication, your doctor needs to listen to you and work with you to find an alternative. I wish you well and hope you can soon find relief.