How Long For Body To "Reset"?

0611945cc,
It may not. And I wouldn't add denosumab to forteo except if I had taken denosumab I would definitely want to add forteo to a bisphosphonate and hope to take advantage of whatever synergy there might be left with the prolia remaining in my system.
Like everyone else, I'm not a big advocate of pharmaceuticals. I am intrigued by the use of concommitant meds for osteoporosis. Much of the literature concedes the advantages, and admit that the lag in this type of prescribing isn't done because of costs and insurance.
Likewise if I were on Prolia and suddenly aware of the disadvantage, I would add tymlos or forteo. If I were on Forteo, I would definitely not add Prolia.

I also think that the fingernails are an indication of what is happening to your bones. Mine are getting harder to clip and I have to clip them more often.

Good thinking. I wish you had an endocrinologist who would order serum CTx.

From McCormick’s book it seems that Alendronate and Actonel are the same in increasing spine & hip . I am thinking about Actonel after my Evenity .

Thank you, Susan, for sharing your friend's experience with Reclast - it gives me some reassurance

In your response to surefire, you suggested the possibility of taking a lower dose to guard against adverse side effects. I think that's a very good idea worth exploring with my doctor. Given that I had taken relatively few (3) doses of Prolia before stopping, perhaps I do not need to take the full dose of Reclast/ Zometa to mitigate the rebound effect.

In fact, your suggestion led me to do some digging and I came across an article which suggests that, in the case of zoledronate, a lower dosage may actually be beneficial. Unfortunately, I am not able to post a link yet, being a new member but the following is a quote:

"Zoledronate has been in clinical use since 2007, and evidence suggesting that less treatment with zoledronate than 5 mg annually might effectively reduce fracture risk has been available for almost as long [Grey et al. 2009]. "

Another thing I have been wondering is, whether the doses of Alendronate that I have taken since stopping Prolia can be taken into account to reduce the dosage of Reclast/ Zometa for the purpose of mitigating the rebound. For eg if I do 6 months Alendronate, can I just do 6-month (half) dose of zoledronate? In other words, would "6 months of Alendronate + 6-months' dose of Reclast" work as well as "12 months of Alendronate"?

It’s all so confusing. My spine t-score is -3.1 and hip -2.7. In a consultation with Dr. McCormick, he said I am on the cusp for taking a medication, but when he found out I ski, he suggested Forteo. My endocrinologist, who is well known in the field of osteoporosis for her research, said I am too young to have a t-score that low (mid-60’s) and recommends Prolia (she steps down the dose before using Reclast), as the bisphosomates aren’t strong enough for me, and the anabolics aren’t necessary because I haven’t fractured. However, when she found I ski, like Dr. McCormick, she recommended an anabolic. I’m consulting again with her on Feb 20th.

Susan, can’t wait to hear how u will do on Reclast . I may go that way also but have till August until my year is up on Evenity .

kristie2,
I am nervous about Reclast, but I was about Evenity, too. And, that has gone well.
I am trying to figure out how much time should pass between Evenity and starting Reclast. I have lost some faith in my endocrinologist. At last appointment, he was just not engaged. Typing on tablet, no eye contact, didn’t know who Keith McCormick was, etc.
when I said that I didn’t want to take Fosamax after Evenity, that I would take Reclast, he just said “Okay.”
No discussion.
At this point, I will take medical advice from this site before trusting my endocrinologist.
A few years ago, I had a doctor who had made osteoporosis her specialty. She was incredibly well informed and had a great relationship with her patients. Tragically, and ironically, she fell at home and died. Everyone knew her. At my last endocrinology appointment, I brought her up. My current lackadaisical doctor said,” I miss her.”
I thought, “Wow. You and me both, Buddy.”

Susan ,
I too am having a hard time looking forward on what the next drug will be . I was so afraid of taking Evenity also . I have a call with my endocrinologist on Wednesday and will see what the next step is in her mind . I’ve had to ask for bone markers etc . I am glad I was well informed before starting this whole process. I don’t have much confidence in her !

I do not have experience with Envity but I did the Reclast infusion because my stomach couldn’t tolerate the Fosamax. Reclast was in September’23 and I’m still having side effects. I had multiple symptoms for 3 months. At 4 months most have improved but I still have severe bone pain in my legs every day. This prevents me from doing normal activities. I started this journey as an active healthy 65 year old and now struggle to get through my days.
I work full time. If I was not able to work from home I would not be able to manage this pain. I caution everyone considering Reclast. I am under the care of my primary. She is wonderful but is learning how to navigate this long with me. She explains my body’s reaction as if it’s fighting a virus. The inflammation has impacted almost every area in my body. Please proceed with caution.