Duration of Crohn’s Disease & Response to Vedolizumab (Entyvio)

Dec 20, 2019 | Kanaaz Pereira, Connect Moderator | @kanaazpereira | Comments (11)

For patients diagnosed with Crohn’s disease (CD), there seems to be an opportune window in which early intervention may improve outcomes of the disease. Dr. Edward Loftus explains details of a multicenter collaborative  study which found that patients with CD, for 2 years or less,  are more likely to achieve a complete response to vedolizumab (Entyvio), than patients with longer disease duration.

Researchers considered several factors to evaluate the relation between disease duration and vedolizumab effectiveness –

  • Clinical remission, defined as absence of symptoms.
  • Corticosteroid-free remission (CSFR), defined as tapering off steroids completely, achieving clinical remission, and no repeat steroid prescription within 4 weeks of tapering.
  • Endoscopic remission, defined as the absence of ulcers and/or erosions in CD.

What are the implications for patient care?

The findings of the study suggest that patients who’ve been diagnosed with Crohn’s disease should begin treatment with an anti-TNF agent or vedolizumab as soon as possible.

Meet other people, talking about Crohn’s disease, on Mayo Clinic Connect – join the conversation, share experiences, ask questions, and discover your support network. Here are some discussions you might like to follow...

 

 

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Not the results I achieved. The colitis continued to get worse until I reached a pointed where I had to have my colon and ultimately my rectum removed. Even 4 years after the surgery, I am still experiencing pressure and extreme discomfort in the rectal area and elsewhere in my abdomen. Wonder if any of the medications used to treat colitis are effective long term or perhaps not at all.

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@kenc

Not the results I achieved. The colitis continued to get worse until I reached a pointed where I had to have my colon and ultimately my rectum removed. Even 4 years after the surgery, I am still experiencing pressure and extreme discomfort in the rectal area and elsewhere in my abdomen. Wonder if any of the medications used to treat colitis are effective long term or perhaps not at all.

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HI..I have had a bad flare of ulcerative colitis..got it when I got Covid december 2021..I have been very ill with it..just had two hospitalizations in a month..missed alot of work, passed out or fainted at work..the doctor that did my colonoscopy last week said that probably happened due to all the inflammation that I had and the colitis had not been treated, or from all the immodium and the budesonide they had me taking. They also prescribed Mesalamine products , which I had many side effects from, then they wanted to push ENTYVIO on me without even doing a colonoscopy first to see what the was causing all my problems. I finally got a doctor to listen to me last week when I was hospitalized again, and he did a colonoscopy on me as soon as they could get the prep done, I have to have another colonoscopy in three months . I see the doctor tomorrow. I would love to connect with you and others regarding the Entyvio. I also have long covid syndrome and feel this was the culprit to me getting so ill. I did have numerous polyps, now awaiting the biopsies reports. I feel like you also. Sincerely..Kitty2

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@kitty2

HI..I have had a bad flare of ulcerative colitis..got it when I got Covid december 2021..I have been very ill with it..just had two hospitalizations in a month..missed alot of work, passed out or fainted at work..the doctor that did my colonoscopy last week said that probably happened due to all the inflammation that I had and the colitis had not been treated, or from all the immodium and the budesonide they had me taking. They also prescribed Mesalamine products , which I had many side effects from, then they wanted to push ENTYVIO on me without even doing a colonoscopy first to see what the was causing all my problems. I finally got a doctor to listen to me last week when I was hospitalized again, and he did a colonoscopy on me as soon as they could get the prep done, I have to have another colonoscopy in three months . I see the doctor tomorrow. I would love to connect with you and others regarding the Entyvio. I also have long covid syndrome and feel this was the culprit to me getting so ill. I did have numerous polyps, now awaiting the biopsies reports. I feel like you also. Sincerely..Kitty2

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I had no luck w/ any of the colitis medications.

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@kenc

I had no luck w/ any of the colitis medications.

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What are you doing..they just want to push Entyvio..and alot of vaccines on me..I did one infusion of remacaide years ago..and it was a nightmere..felt terrible after that infusion..nothing is working for me either. Thanks Kitty2

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@kitty2

What are you doing..they just want to push Entyvio..and alot of vaccines on me..I did one infusion of remacaide years ago..and it was a nightmere..felt terrible after that infusion..nothing is working for me either. Thanks Kitty2

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The only thing that worked for me were steroids, I have been through it all. Ended up having my colon and rectum removed with promises of glowing recovery. Didn't happen. Even w/ using a spinal stimulator, I have bouts of severe rectal pain. Hope your continued quest for treatement works out better than mine.

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@kenc

The only thing that worked for me were steroids, I have been through it all. Ended up having my colon and rectum removed with promises of glowing recovery. Didn't happen. Even w/ using a spinal stimulator, I have bouts of severe rectal pain. Hope your continued quest for treatement works out better than mine.

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I am thinking of you and what you have gone through…since I have been off all the mesalamine I am starting to feel better…side effects of that drug are bloody diarrhea..I think that was making me so much worse..I hope you start feeling better..please stay in touch..sincerely kitty2

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@kenc

I had no luck w/ any of the colitis medications.

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What all have you taken? I think all the mesalamine and immodium they had me on made me worse..I am starting to get feel better since stopping all that stuff..side effects are bloody diarrhea from both of them…also dizziness..I actually passed out or fainted while I was at work. What are you doing now? Kitty 2

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My husband has had Crohns all his life. He had a temporary colostomy at 40 yrs old, reversed a year later then permanent one a year later. He tried Humira monthly infusion treatments at 50 but he became diabetic so switched to Remicade. He is 76 and going strong. What worked: he was old school and still does morning enemas to remove waste and gets the day off to a good start, 6 weeks Remicade infusions, and gets vaccines. No pain, no flares but sticks to a routine. It is genetic in his family.

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@rose999

My husband has had Crohns all his life. He had a temporary colostomy at 40 yrs old, reversed a year later then permanent one a year later. He tried Humira monthly infusion treatments at 50 but he became diabetic so switched to Remicade. He is 76 and going strong. What worked: he was old school and still does morning enemas to remove waste and gets the day off to a good start, 6 weeks Remicade infusions, and gets vaccines. No pain, no flares but sticks to a routine. It is genetic in his family.

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With his colonscopy, why is he taking remicade infusions?

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Crohns is never gone no matter what you do. Remicade reduces symptoms. Crohns attacks you from tip of tongue to end of rectum. His was lower end for the colostomy-his colon ends around waist line. The stoma is moved surgically when needed.

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