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Comments (2,564)

Hi all with Sjogrens syndrome, I was diagnosed in 1988 when the gland areas all around...

https://connect.mayoclinic.org/comment/111262/

&A but my astute doctor prescribed Methotrexate ... The Methotrexate completely resolved

Discussion: Sjogren’s Syndrome – Introduce yourself and meet others

Support Group: Autoimmune Diseases

Posted: Jan 25, 2017

My husband was diagnosed in early June. He had been on different doses of prednisone but...

https://connect.mayoclinic.org/comment/1194533/

So then Doctor added methotrexate and ... has had to increase prednisone and methotrexate

Discussion: Just Started Actemra

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Dec 21, 2024

I just started Methotrexate 10 days ago and I have taken it two Friday/Saturdays so far....

https://connect.mayoclinic.org/comment/1328317/

I just started Methotrexate 10 days ... blown headache) since I started the Methotrexate

Discussion: Has anyone experienced dizziness with medication for PMR?

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Jun 16, 2025

Well he said he would evaluate the situation with the Prednisone and depending on how I'm...

https://connect.mayoclinic.org/comment/1382786/

I'm doing MAY possibly give me methotrexate

Discussion: Bilateral Muscle Pain in Arms, Legs, Neck and Shoulders

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Aug 30, 2025

Did your Dr give you any advice? Maybe methotrexate is not the correct biologic for you....

https://connect.mayoclinic.org/comment/1391672/

Maybe methotrexate is not the correct

Discussion: Weaning off of all medicine - prednisone and methotrexate

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Sep 11, 2025

Interesting in that my wife cannot take Methotrexate (allergic reaction). Not sure about the post Pfizer...

https://connect.mayoclinic.org/comment/854998/

Interesting in that my wife cannot take Methotrexate

Discussion: My wife has autoimmune disease. She has inflammation in legs and arms.

Support Group: Autoimmune Diseases

Posted: May 5, 2023

since you are on methotrexate keep tabs on your liver enzymes. i was on that for...

https://connect.mayoclinic.org/comment/145452/

since you are on methotrexate keep tabs

Discussion: Rheumatoid Arthritis (RA) - Introduce yourself and meet others

Support Group: Autoimmune Diseases

Posted: Aug 31, 2019

I am being seen by the University of Texas medical center. She is not what I...

https://connect.mayoclinic.org/comment/96811/

I believe that the Methotrexate was

Discussion: Chronic Pain members - Welcome, please introduce yourself

Support Group: Chronic Pain

Posted: Mar 6, 2018

I am curious about several things. First, did you taper directly from 20 mg to 15...

https://connect.mayoclinic.org/comment/624103/

Second why plaquenil rather than methotrexate

Discussion: Plaquenil and PMR

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Aug 7, 2021

Thanks for your reply: I take a 1 MG tablet of folic acid daily. I take...

https://connect.mayoclinic.org/comment/1204814/

I take (6) 2.5 MG tablets of methotrexate

Discussion: New Kid on the block with several questions

Support Group: Neuropathy

Posted: Jan 5, 2025

I started 4 pills methotrexate once a week to start reducing from 12mg Medrol. Additionally I...

https://connect.mayoclinic.org/comment/762933/

I started 4 pills methotrexate once

Discussion: Experience with Methotrexate?

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Oct 18, 2022

Thank you. I haven't thrown in the towel yet but running out of medical options. The...

https://connect.mayoclinic.org/comment/319605/

We already tried methotrexate which

Discussion: Autoimmune something: Struck with extreme fatigue

Support Group: Autoimmune Diseases

Posted: Aug 23, 2020

@johnbishop thanks John. I will check it out. Logically, when you have an autoimmune disease, the...

https://connect.mayoclinic.org/comment/916020/

give you drugs like prednisone or methotrexate

Discussion: Fasting and autoimmune diseases, does it help?

Support Group: Autoimmune Diseases

Posted: Aug 20, 2023

I completely understand about not trying anything new and untested-- I got PMR after having Covid...

https://connect.mayoclinic.org/comment/871039/

I'm about to start as Methotrexate

Discussion: Kevzara (sarilumab) to treat PMR

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Jun 2, 2023

I was diagnosed with GCA three months after you. I started with 40 mg Prednisone and...

https://connect.mayoclinic.org/comment/197132/

going to Rheumatologist who added Methotrexate

Discussion: Medications for Temporal Arteritis/Giant Cell Arteritis (GCA)

Support Group: Polymyalgia Rheumatica (PMR)

Posted: May 11, 2018

The Methotrexate prevents the body from excreting excess B12. My B12 results were at a toxic...

https://connect.mayoclinic.org/comment/1258431/

The Methotrexate prevents the body from

Discussion: Excess B12 possibly causing numbness and tingling

Support Group: Neuropathy

Posted: Mar 15, 2025

@dunbun13 I had collagenous colitis- I would take Imodium and Lomotil before I would leave the...

https://connect.mayoclinic.org/comment/1282143/

Once diagnosed I got methotrexate for

Discussion: Colitis worsening. Do you take a prescription for it?

Support Group: Digestive Health

Posted: Apr 14, 2025

Luckily I haven’t had any side effects except perhaps worse fatigue. Methotrexate made me throw up....

https://connect.mayoclinic.org/comment/748733/

Methotrexate made me throw up.

Discussion: Anyone tried Actemra (Tocilizumab) to treat PMR? FDA approved for GCA

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Sep 12, 2022

I did mention it to the rheumatologist…he went straight into a talk about essential tremor. I...

https://connect.mayoclinic.org/comment/737343/

I have taken the methotrexate for 30

Discussion: Leg weakness and hand tremors

Support Group: Brain & Nervous System

Posted: Aug 14, 2022

I was on methotrexate for 5 years. The nausea goes away but until it does, take...

https://connect.mayoclinic.org/comment/1095201/

I was on methotrexate for 5 years.

Discussion: PMR and Methotrexate

Support Group: Polymyalgia Rheumatica (PMR)

Posted: Jun 27, 2024