Welcome to the online home of the Chris M. Carlos and Catherine Nicole Jockisch Carlos Endowment for Primary Sclerosing Cholangitis (PSC). Thanks to support provided by this endowment, dedicated Mayo Clinic investigators and their teams are making strides to better understand and treat PSC patients, with the ultimate goal of developing a cure for this disease.
Follow the PSC page and stay up-to-date as we post news about advances in PSC research, clinical trials, and available resources.
Mayo Clinic is at the forefront of research designed to uncover the environment’s role in PSC, thanks to a unique collaboration with Gary Miller, PhD, a toxicologist and Professor of Environmental Health Sciences and Vice Dean, Research Strategy and Innovation, at Columbia University.
Dr. Miller’s interest in figuring [...]
This past year, our PSC team accomplished several important milestones that make us proud: We received an NIDDK award to study the pathogenesis and outcomes of PSC for the next five years, launched our PSC blog via Mayo Clinic Connect, and published several seminal papers to improve the knowledge [...]
Human environmental exposures and corresponding metabolic responses are highly variable, and may contribute to disease in genetically susceptible individuals. Recently, ultra-high resolution mass spectrometry (HRMS) has allowed precise detection of over 50,000 signals, revolutionizing the ability to measure biologic responses (metabolomics) to cumulative exposures such as environmental toxicants, diet, [...]
Primary Sclerosing Cholangitis (PSC) often strikes without a patient noticing any symptoms or signs of disease. For Nicole Jockisch Carlos, an Atlanta resident, this was the case.
Bloodwork ordered by her doctor in advance of a fitness competition revealed elevated liver enzymes. Although Carlos shared with her doctor [...]
When Dr. Nicholas LaRusso arrived at Mayo Clinic for a three-month elective during his fourth year of medical school, he knew where he wanted to be.
“Mayo Clinic was like the Emerald City. While I loved my training in New York where I worked at one of the [...]