In a recent paper published in the Journal of Gastroenterology, Bakhshi et al., reported an update on the epidemiology and outcomes of Primary Sclerosing Cholangitis (PSC) in a population-based cohort. The authors found that the incidence (i.e., the occurrence of new cases per year) of PSC almost doubled from 2001 to 2017 compared to the period from 1976 to 2000. Importantly, patients with PSC were increasingly being diagnosed with milder disease. The intra-individual variation of serum alkaline phosphatase was high, thus, questioning the use of this biochemical marker as an endpoint in clinical trials.
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