Learn more about bone marrow transplants (BMT) and CAR-T therapy with Mohamed A. Kharfan Dabaja, M.D., M.B.A. Dr. Kharfan-Dabaja gives an overview of treatment options and then fields questions from Mayo Clinic Connect and Facebook members.
Bone marrow transplants are now also known as hematopoietic stem cell transplants. There are two types of hematopoietic (BMT) transplants, autologous and allogeneic.
An autologous transplantation is when a patient uses cells from their own body. The process for autologous transplantation is as follows:
Allogeneic transplantation uses cells from a donor — typically a matched related donor such as a child or parent. The process for an allogeneic transplantation is as follows:
Follow up appointments for each transplantation monitor for recovery and assessments of the disease. Also, appointments will monitor for infections due to the lowered immune systems because of the procedure itself.
Our bodies contain cells, in this case T lymphocytes, that fight against infections and against cancer. Sometimes, those cells do not function properly or they do not recognize cancer cells. In short, CAR-T therapy isthe re-engineering of your T-cell lymphocytes:
Patients must meet specific criteria for approved disease that qualify for CAR-T therapy, as well as physical exams to determine the patient can handle CAR-T therapy.
Tune in to the 8:30 minute mark of the video to watch Dr. Kharfan-Dabaja answer questions from Connect and Facebook members.