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In a recent paper published in the journal Clinical Gastroenterology and Hepatology, Stokkeland K. et al., reported the effects of exposure to medications on the outcomes of PSC using a population-based cohort of 2,914 patients from Sweden. The authors found that use of statins or azathioprine, among patients with PSC, was associated with reduced risk of all cause mortality, death or liver transplantation. Of note, exposure to ursodeoxycholic acid did not affect the mortality of these patients. Despite the retrospective nature of this study, these interesting findings suggest pursuing further investigation on the role of statins in the outcomes of PSC.
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Interesting information. My first diagnosis of what turned out to be PSC was about 40 years ago. During a routine physical prior to a trip to Japan and Korea my liver enzymes were off the chart. No real diagnosis was made, and the diagnosis was not made until I changed states and doctors. In 2002 I was diagnosed with small duct PSC through a live biopsy. Liver enzyme levels continued to be high. In 2010 I stared on Simvastatin. 40mg once a day. In 2014 it was reduced to 20mg per day. Starting about 6 years ago all of my liver enzymes have been in the normal range. I have never suffered from other PSC related issues like jaundice or itching. I did have chronic ulcerative colitis and was on Remicade for roughly 5 years. In 2012 I had Ileal Pouch Anal Anastomosis (IPAA) surgery at the Mayo Hospital in Phoenix.