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Tue, Jun 12 12:30pm

Mayo Clinic Transplant Innovations

By Kristin Eggebraaten, Relations Coordinator, @keggebraaten

Transplant medicine has made amazing progress in the last 50 years, with new research and surgical techniques saving thousands of lives worldwide. In 2017, a record number of more than 34,000 transplant surgeries were performed in the U.S. I have worked in the Transplant Center at Mayo Clinic's campus in Rochester, Minnesota, for nearly 20 years. Just during the time that I have been with Mayo, processes and procedures have changed the way we care for patients and have allowed us to perform more transplants than ever before.2018-05-29 Innovations Blog Post

In 1963, Mayo Clinic officially entered the field of transplantation with a bone marrow and kidney transplant. Today Mayo is the largest integrated transplant provider in the U.S. performing more than 2,000 transplants each year. While some innovations are still in clinical trials, some of these transplants were made possible by innovative transplant procedures, research and medical advances pioneered by Mayo Clinic. Here are just a few transplant-related innovations that have occurred in the last few years at Mayo Clinic.

Laryngotracheal Transplant

Dr. David Lott came to Mayo Clinic's campus in Phoenix, Arizona in 2011 on a mission – to start a laryngotracheal transplant program – the first in the U.S. Dr. Lott is embarking on a five-year clinical trial of 10 laryngotracheal transplant patients. “We have a handful of patients waiting for the trial to commence,” he says. “Mayo wants to be at the forefront of transplant medicine, and this will be the world’s first full-fledged laryngotracheal transplant program. We’re excited to change the lives of these patients.” In addition to the laryngotracheal transplant program, which will use cadaver larynges, Dr. Lott and his team are working on a bioengineered larynx program. They’ll use a patient’s own stem cells to create tissue to replace the damaged areas of the larynx and trachea. Over several weeks of special treatment, the stem cells will grow new tissue on a patient-specific scaffold made on a 3-D printer in a new cell therapy laboratory at Mayo Clinic.

Regenerative Medicine

Due to a nationwide organ shortage and never-ending quest to find the best answers, medical science can provide, Mayo Clinic researchers are studying alternatives to transplant including using stem cells to repair, replace or regenerate diseased cells. Researchers study and test how reprogrammed stem cells may be turned into specialized cells that can repair or regenerate cells in the heart, blood, nerves and other parts of the body. These stem cells have the potential to treat many conditions and could eliminate many of the long waits on the transplant waiting lists.

Liver Ex Vivo Perfusion

When a liver is removed from a donor for transplant, surgeons typically have less than 12 hours to transplant that liver into the recipient. Current practice is to place the liver in cold storage in a preservation solution at 4 degrees Celsius. Dr. Andrew Singer of Mayo Clinic's campus in Phoenix, Arizona is the principal investigator for a clinical trial to increase that preservation time for as long as 24 hours, using a perfusion system that keeps the liver at a temperature that simulates the human body. Dr. Singer believes this new system will give surgeons longer time to transport livers over longer distances – which could minimize deaths on the waiting list by allowing the sickest patients to have those organs regardless of where they are located around the country.

Liver Regeneration

We talked above a little bit about regenerative medicine, but what if liver disease could be cured by using a patient’s own cells to correct their liver disease? Dr. Scott Nyberg of Mayo Clinic's campus in Rochester, Minnesota has spent his professional life perfecting such a system. Dr. Nyberg is trained as a transplant surgeon and biomedical engineer, and his vision for the future is to engineer livers to address the organ shortage. Sometimes livers are donated that are not able to be used for transplant. Dr. Nyberg uses these livers in his research. He removes all the cells from the liver and replaces those cells with cells from a patient, creating a whole new organ. He and his colleagues hope to someday help eradicate the waiting list and eliminate the need for more deceased organ donors for patients with liver failure.

Even with the high transplant volumes, the rising number of organ donors, and the medical and surgical innovations that continue to be discovered, twenty people in the U.S. still die each day waiting for an organ. There’s more work for us all to do – more medical and surgical innovations to research, more opportunities to promote organ donation and more advances to put to use for our patients.

What do you think will be the next big transplant innovation?

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COMMENT

beckyjohnson
@beckyjohnson

Posts: 204
Joined: May 30, 2018
Posted by @beckyjohnson, Tue, Jun 12 6:02pm

@jerrydrennan What a positive article. It gives reason for hope.

IWantToBelieve
@IWantToBelieve

Posts: 325
Joined: Feb 11, 2017
Posted by @IWantToBelieve, Wed, Jun 13 10:24pm

I'd love to see an artificial kidney to avoid dialysis until a transplant is possible.

beckyjohnson
@beckyjohnson

Posts: 204
Joined: May 30, 2018
Posted by @beckyjohnson, Wed, Jun 13 11:04pm

@IWantToBelieve Would donors even be needed when artificial kidneys become perfected like well made prostheses? Stem cell transplants seem to be promising as well. It is all very exciting when considering 50 years ago there was very little hope for quality living upon renal failure diagnosis.

tinasue60
@tinasue60

Posts: 1
Joined: Aug 06, 2018
Posted by @tinasue60, Mon, Aug 6 11:51am

Will they do a kidney transplant if the patient has a cold?

gingerw
@gingerw

Posts: 28
Joined: Jul 26, 2018
Posted by @gingerw, Mon, Aug 6 9:53pm

@tinasue60, I don't think so. My husband was transplanted 1 Oct 2016, and they were very careful. Since your body is already fighting the intrusion of a cold, your immune system is compromised. A transplant needs an optimum playing field to start out.

Posted by @rosemarya, Tue, Aug 7 6:49am

@tinasue60, I found a Transplants Group Discussion that I would like to share with you. – "Can a cold or ear infection delay getting a transplant?"

https://connect.mayoclinic.org/discussion/question-204e2a/

I would encourage you to also speak to your own transplant team about your own individual circumstances.

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