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Comments (66)

I have myoclonus leg jerks any time I get drowsy. They hurt. I can imagine how...

https://connect.mayoclinic.org/comment/265623/

Discussion: Have you ever had hiccups with or after chemotherapy?

Support Group: Cancer: Managing Symptoms

Posted: Jan 24, 2020

I’m suffering the same way. Legs so weak I can barely do stairs. Is it the...

https://connect.mayoclinic.org/comment/962170/

Discussion: Lupron: Anyone have muscle weakness and severe leg pain?

Support Group: Prostate Cancer

Posted: Nov 10, 2023

Thank you for your post. So encouraging to hear success stories and faith. Made my day....

https://connect.mayoclinic.org/comment/919010/

Discussion: Lupron: Anyone have muscle weakness and severe leg pain?

Support Group: Prostate Cancer

Posted: Aug 26, 2023

I think my instability comes from weakness in my legs and I regularly exercise hard to...

https://connect.mayoclinic.org/comment/814398/

Discussion: Lupron Depot: Weakness and instability side effects

Support Group: Prostate Cancer

Posted: Feb 20, 2023

My last three month injection was in early February. I have no libido, weak muscle tone...

https://connect.mayoclinic.org/comment/601485/

Discussion: How long do Lupron side effects last after treatment concludes?

Support Group: Prostate Cancer

Posted: May 13, 2021

As said, everyone is different. In my case, hot flashes began about 4 weeks in. They...

https://connect.mayoclinic.org/comment/1455912/

Discussion: ADT: How long until I can expect the hot flushes to kick in?

Support Group: Prostate Cancer

Posted: Dec 8, 2025

Been on Orgovyx for just about 11 months. (Gleason 7 (4+3) with seminal vesicles invasion. Did...

https://connect.mayoclinic.org/comment/1445756/

Discussion: Has anyone experienced leg pain while taking Orgovyx?

Support Group: Prostate Cancer

Posted: Nov 23, 2025

Hi tj1967, looks like you got a lot of excellent replies and advice. The only issue...

https://connect.mayoclinic.org/comment/1408562/

Discussion: Orgovyx - asking for advice

Support Group: Prostate Cancer

Posted: Oct 4, 2025

After Xtandi no longer worked and after my husband's first Pluvicto, his PSA rose to over...

https://connect.mayoclinic.org/comment/1271850/

Discussion: Can anyone share their experience with Pluvicto?

Support Group: Prostate Cancer

Posted: Apr 1, 2025

I’m on Lupron every 6 months along with prednisone daily. After my first injection 6 months...

https://connect.mayoclinic.org/comment/1160636/

Discussion: Lupron treatment and Fatigue...

Support Group: Prostate Cancer

Posted: Oct 21, 2024

I had weakness in my legs (paralysis, eventually) because a bone metastatis compressed my spinal cord....

https://connect.mayoclinic.org/comment/1153111/

Discussion: Leg Issues Long After Radiation and ADT

Support Group: Prostate Cancer

Posted: Oct 6, 2024

I identify with your leg pain. Gleason 9. Metastatic. I’ve done chemo and radiation, now on...

https://connect.mayoclinic.org/comment/957594/

Discussion: Lupron: Anyone have muscle weakness and severe leg pain?

Support Group: Prostate Cancer

Posted: Nov 1, 2023

kam23, Thanks for posting this. I indeed had similar symptoms, and felt the same as you...

https://connect.mayoclinic.org/comment/898630/

Discussion: Lupron: Anyone have muscle weakness and severe leg pain?

Support Group: Prostate Cancer

Posted: Jul 19, 2023

Very interesting. I took Lupron for 25 months mostly with 6 month shots. After several I...

https://connect.mayoclinic.org/comment/884745/

Discussion: Lupron dosing: side effects for 3 month dose vs. monthly dose

Support Group: Prostate Cancer

Posted: Jun 25, 2023

I was diagnosed with stage 4 metastatic castrate resistant prostate cancer in February 2019. Treat was...

https://connect.mayoclinic.org/comment/779117/

Discussion: Chemotherapy for stage IV prostate cancer

Support Group: Prostate Cancer

Posted: Nov 30, 2022

@7506ian , welcome to the discussion none of us "want" to be in. Knowledge is power...

https://connect.mayoclinic.org/comment/766420/

Discussion: Chemotherapy an option for prostate cancer?

Support Group: Prostate Cancer

Posted: Oct 28, 2022

@dantadams I have very low T (20s) as well but my DR does not recommend supplementing...

https://connect.mayoclinic.org/comment/1412692/

Discussion: Looking for feedback - Lupron vs Orgovyx

Support Group: Prostate Cancer

Posted: Oct 10, 2025

Simplest answer: "Start slow" and "listen to your body." I did not go back to the...

https://connect.mayoclinic.org/comment/1390901/

Discussion: Working out after RARP

Support Group: Prostate Cancer

Posted: Sep 10, 2025

My PSA climbed steady for 2 years and I kept putting off the recommended Colonoscopy. I...

https://connect.mayoclinic.org/comment/1322719/

Discussion: For Newly Arrived Bros: A Day In The Life With ADT

Support Group: Prostate Cancer

Posted: Jun 8, 2025

YES!. Much like Lupron which I quit due to SE's Shortness of breath VERY dry mouth...

https://connect.mayoclinic.org/comment/1303846/

Discussion: Has anyone had severe side effects from abiraterone (Zytiga)?

Support Group: Prostate Cancer

Posted: May 14, 2025

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