Rebuilding muscle mass post-Lupron

Posted by cbinvt @cbinvt, Jan 7 2:32pm

I was on Lupron for 12 months and received my last six-month shot in June 2022. I underwent proton radiation treatment in March/April 2022. My PSA dropped from 45 pre-Lupron and radiation to undetectable in November 2022.

With my doctor's agreement, I did not receive another Lupron shot in December 2022 because I wanted to build up muscle mass for a long-planned four-day hike to Machu Picchu in May 2023.

I continued daily exercises and hikes throughout my treatment, but I am conscious that my strength and endurance have dropped significantly. I'm currently working with a personal trainer, but I still feel much less strength on long uphill sections of my daily hike. I'm really concerned that I may not have the leg strength to complete my fairly demanding four-day hike in May.

I'd love to hear others' advice on how long it takes to rebuild muscle mass after the effects of Lupron have moved out of the system.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

I have had stage IV prostate cancer for about three years now. My early treatment included the lupron on the theory that high testosterone fed the growth of cancer cells. I have been off the lupron for about a year and a half. Doctor wanted me to go back on it recently as psa began to rise significantly and my testosterone was high. I was not convinced of the inevitable relationship between high testosterone and rising psa so I declined, at least until more time had passed. If my psa continued to rise significantly I told him I would go back on the lupron. What happened was my testosterone increased significantly while my psa dropped significantly. I am not back on the lupron.

I, too, exercise regularly in the attempt to regain muscle mass, strength, and stamina. I generally don't feel too bad, but in spite of my regular exercise my strength and stamina is not coming back. I only have seen marginal improvement.

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I did 18 months of Lupron in concert with six cycles of taxotere and 25 radiation treatment to the PLNs (see attached clinical history). As they say, study of one but throughout that period I exercised regularly, swam, elliptical, indoor and outdoor biking, played basketball, went skiing and hiking in Colorado, walked my dog, did the lawn and gardening work, lifted weights, even did the Bataan Memorial March in White Sands. NM with my sister, a 26.2 mile "hike in the desert, of course, my time sucked…. I was 62 when I started and generally a lifelong active person. That's not to say I didn't feel the affects of those treatments, there were some days during the taxotere cycles where doing 10-15 minutes on the elliptical vice 30-45 were a challenge, once I set out on a 20-25 mile bike ride and had to call my daughter after 16 to come get me!

I did gain weight, about 10-15 pounds, when my GP commented on it I reminded her of the Lupron and the affects of low T on metabolism…lost it after I went off treatment.

So, you're doing the right thing, regular exercise along with diet, managing stress….one thing I think may have played into my situation was the proverbial mind over matter, I believe it's a powerful things.

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Thanks for these helpful reactions. Does anyone know how long it takes post-Lupron for exercise to begin building muscle mass? Theoretically, the six-month Lupron shot I received in early June "expired" at the end of November. However, seven weeks of serious exercise later, I'm still feeling challenged climbing long stairs and don't feel any improvement in my leg muscle strength endurance. Any thoughts?

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@cbinvt

Thanks for these helpful reactions. Does anyone know how long it takes post-Lupron for exercise to begin building muscle mass? Theoretically, the six-month Lupron shot I received in early June "expired" at the end of November. However, seven weeks of serious exercise later, I'm still feeling challenged climbing long stairs and don't feel any improvement in my leg muscle strength endurance. Any thoughts?

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The shots actually linger past the 6 month period. Took me a couple months past for my original shots to wear off. You would have to do a testosterone level to find out for sure.

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I'm Phase IV three years in and on ADT. I Exercise moderately daily. Tia Chi, Walking, Bands, Light Weights, Swim, and Indoor Biking. Strength, endurance, are track with an app. Everything progressing slowly. If I walk/Swim/Bike for more than 30 minutes bone pain sets in the next day and last for a couple of days. I tend to do 60-90 minutes of exercise type movements per day. Measuring my strength and endurance helps, my goal is tiny increments per month, Some months are better than others.

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