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Enzalutamide (Xtandi): Anyone have experience with this drug?
RP in 2004. Over the past few years PSA has been rising. On Lupron for the last 12+ months. Bone scan in Jan of 2022 indicated cancer has spread to pelvic area bones. Bone scan in Jan of 2023 indicates it is slowly spr3eading.Dr. is putting me on Xtandi next week. I am curious if anyone out there has been on this drug. Sounds like I will stay on Lupron also. Before the Lupron started a year ago my PSA was 67. believe II may be having problems again with Pancreatic cancer (Whipple in early 2019). Regardless, life is good. I have complete trust in my Oncologist.
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My thoughts for you.
My Gleason scores were all 10 (12-14 counts) stated Lupron in 2012, HDR Brachytherapy in 2012. Still on Lupron today. I was on bicalutimide , followed by Zytiga, and now Xtandi.
Zytiga made me nauseous and I could not take a full dose without throwing up. So I usually took two pills in the morning and two pills at night. It seem to keep my PSA and check. At one point in 2017 my urologist thought I was in such a good spot that he suspended my next injection of Lupron. Immediately my cancer spread to my bones and I have had issues ever since. It was only a six month window but it created lots of havoc in my life. In 2021 the bone cancer became very painful and he switched me from Zytiga to Xtandi and now I am on Ebearla. I Xtandi caused very little issues with me and I tolerate it well. Ebearla I is the same, I have no issues tolerating it. And between the Lupron and the Eberle, my numbers have gotten back down and the two range. They were as high as 30.
All three of those medication‘s tended to decrease my metabolism, make me lethargic, and eventually have led to a few extra pounds. But I still go golfing and riding my bike and babysitting the grandkids. Overall, I would say life is pretty good. I would encourage you to do as much reading and research towards cancer cures versus just treatment.
I was on lupron and Erleada with RP for a year in a clinical trial. My PSA was 9 now .01 The meds were noticeable but not terrible I am off of meds now and feel great. My doctor said if the cancer returns he will probably put me on lupron and Erleada again. Lupron and Erleada is ok
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1 Reactionps My reading about the clinical trial is that Erleada delays the cancer progression by an average of 24 months over just Lupron providing that you can tolerate the side effects, and the side effects were tolerable for me
@dakotarunner, I believe in addition to @dirtdancer and @hbp, @norske46 @donnelson @melcanada @juangui @swe1205 @fugiamaabc @alanr @scv57 may have experiences with enzalutamide (Xtandi) that they can share.
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1 ReactionI have been on Lupron plus Xtandi for the past six months since rising PSA and PET scan diagnosed mets in bone and lymph nodes. I do experience hot flashes and fatigue; however, the drugs seem to be working so far. Testosterone has come down to 9 and PSA is down to 0.1. I have inquired about adding the LU-177 but can't do it because my blood counts are too low due to a blood cancer (MDS) with very low white and red cell counts. Fatigue is probably also related to anemia from the MDS. Also, I can only take half the dose of Xtandi due to its interaction with Plavix which I am currently taking for heart issue.
Look into Hemo Him front Japan sold in 🇺🇸 a liquid for blood cells immunity
I have been taking Xtandi for 1-1/2 years now. It has kept my PSA below 1 but the PSA is starting to creep up.
For me the biggest side effect are chills which are worse in the mornings. I would say that I tolerate Xtandi no better than moderately.
I have been on Xtandi for 1-1/2 years and it has been effective at keeping my PSA below 1.0
I don’t know anything about Lutron so I cannot comment on how well the drugs will interact.
Oncologists say average effectiveness is 18 months
What would likely come after Xtandi loses effectiveness?