Anyone taken Xeloda for a long period of time: Side effects?

@mustang08 I was on 1350 a dose twice a day but quit working after 1 year now what kind of cancer does he have

Have taken Xeloda for a year but it just now stopped working I had no problems with it except diarrhea and took over counter anti diarrhea med took it 2 weeks on 1 week off

Two years later still taking Xeloda Recently reduced to 2500 mg day to heal hand foot syndrome. Golfs 18 and plays pickle ball and sleeps a lot but good otherwise

I have been on xeloda for 5 months, i had the same problem with feet, i started using asper cream 3 in 1 and jell socks that you can get from amazon or walmart, it works i dont feel like walking on needles anymore, hope this helps

My husband has irreversible chemo induced neuropathy which started as a side effect of oxiliplatin. He takes Xeloda 3000mg a day. Gabapentin plus cymbalta plus over the counter Nerve Renew (b vitamins) has controlled it fairly well. Stage IV rectal cancer with liver metastasis. 20% urea cream helped with skin cracking and peeling. But the disease is stable after 16 mos so that’s good.

for feet neuropathy, I am taking pregabalin ( lyrica) x 2 per day (75 mg) , I have meaningful reduction in numbness and shooting pains, I will have a meaningful increase in numbness if I skip a dose

Sue l, I’m on 2000 mg of xeloda daily for MBC and experience the hand foot issue too. I am doing clobetasol and Urea 10 cream (OTC) twice a day. They help with the dryness and cracking but hardly eradicate the problem. Sometimes I throw on Vaseline for a little extra protection. My question is for anyone else using creams and lotions. Can you put a sock or nylon over the creams. Especially in the morning I have to get to work and don’t have time to let everything dry.
Good luck Sue. I’m wishing everyone the best

I’m thankful to have stumbled upon this thread. I’m newly diagnosed Stage 2 colon cancer. I had my sigmoid colon removed which is where the tumor (7 cm) was. It had wrapped around to the other side and attached to my right ovary, Fallopian tube and appendix and cecum so they removed all. I had 0/28 nodes affected, and clean margins. Because I’m considered high risk (I’ve had ulcerative colitis for 25 years), I will be doing Xeloda and oxiplatin. I start on July 2. The side effects scare me, but I was able to see how my sister dealt with the hand and foot syndrome (she just finished treatment for breast cancer). I will be doing 3 cycles of Xeloda and oxiplatin as my oncologist said recent research shows that 3 months is just as effective as 6.
The nurse said keeping my hands and feet super moisturizer and wearing socks at night will help. She also said wear shoes at all times.
Any other tips?

I am currently on 1000mg of Xeloda twice daily. One week on and one week off. I have hand foot syndrome from the side effects of the medicine. I have tried all kind of lotions, Urea, and Triamcinolone. It is extremely hard to walk for long period of times or know what kind of shoes to wear. I understand friction is bad for them but it is kind of hard to walk with no friction! Just wondered if anyone has suggestions. Thanks!

Welcome To Connect, @mjjc.

May I ask if you could share more details? There are many members who’ve written about Hand-Foot syndrome (HFS) – skin reaction that appears on the palms of the hands and/or the soles of the feet as a result of certain chemotherapy agents – and it will also help me bring other people into the conversation. I look forward to getting to know you.