With regional lymph node metastasis what is the progression?

Posted by transreductionist @transreductionist, Jul 11 9:35pm

From the following summary what should I expect going forward other than Androgen Deprivation Therapy (ADT)?

SUMMARY

2020-06 Prostatectomy

Pathology:
Gleason 4+3
T3
Positive surgical margins
Perineural nerve invasion
Invasive carcinoma (cancer in surrounding healthy tissue)

2021-04 Salvage radiation therapy (SRT) started
2021-06 Salvage radiation therapy ended
2024-07 Undetectable PSA end of SRT to here
2024-09 PSA at 0.02
2025-04 PSA at 0.03
2025-07 PSA at 0.03

I was told that the cancer is probably in the lymph nodes at this stage. With such low PSA levels, it would appear to me to be oligometastatic.

Other than Androgen Deprivation Therapy (ADT), what should I expect going forward? Are low PSA levels like 0.03 typical of the start of metastatic progression? Any other context someone might give would be appreciated. I have read that the 5-year survival rate for regional lymph node involvement is 100%.

Regards,

Aaron

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for dma053 @dma053

My husband went from undetectable after radiation to .02. Had the PSMA Pet Scan and found the cancer in 3 regional lymph nodes- 2 of which were in his chest. He is now on ADT Therapy and in remission. They told us it has more to do with “doubling time” then the actual PSA level.

Jump to this post

They did a PSMA pet at .2 and it actually showed the metastasis at that low PSA?

I know of someone who has been going in for tests at that level, but other people have been a little bit dubious about whether or not it actually would show anything.

Good to hear!

REPLY
Profile picture for jeff Marchi @jeffmarc

They did a PSMA pet at .2 and it actually showed the metastasis at that low PSA?

I know of someone who has been going in for tests at that level, but other people have been a little bit dubious about whether or not it actually would show anything.

Good to hear!

Jump to this post

Yes - we were very lucky they caught it before it spread even further. He’s in remission now but will probably be on ADT therapy indefinitely. And… his PSA was never really high. More that it kept trending upward.

REPLY
Please sign in or register to post a reply.