What to bridge when tapering off effexor

Posted by julishka @julishka, 13 hours ago

Hi, My doctor and I have come up with a plan to taper off 75mg Effexor which I have been on for 15 years. She gave me the choice to bridge during the last dose change with either gabapentin, cymbalta or prozac. I have researched all and am leaning toward prozac. I do have chronic pain as well so wondering if either of the others may be more helpful.

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I have read that Prozac is good for helping with avoiding withdrawal because it has a longer half life. I don't know if that is what is meant as a "bridge." And that may be true of Cymbalta. Does your doctor have a preference?

Personally I would prioritize minimizing withdrawal (having seen the effects in a family member) vs pain relief. Then dealing with pain after fully off. SSRI"s are supposed to help with pain receptors but not sure if that is true of Prozac (or Cymbalta) so maybe that is something to ask.

Gabapentin, in our experience, is good for neurological pain (if tolerated) and helps with anxiety.

Your doctor sounds like a good one !

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@julishka
I'd be curious why the doctor wants to add medication when your trying to get off it unless he's trying to stop your effexor to quickly. I'm wondering if your doctor is not taking into account the length of time you've been on this medication. This isn’t a medication you should expect to get off of quickly. Although bridging may be necessary for some people personally I would never do it since I've always gone off medications extremely slowly. It's been my experience that doctors often try to reduce your medication at two quickly thereby causing withdrawal effects. I stopped some powerful medications and all without any withdrawals and and I credit doing it slowly. as the reason.
Take care,
Jake

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@jakedduck1

@julishka
I'd be curious why the doctor wants to add medication when your trying to get off it unless he's trying to stop your effexor to quickly. I'm wondering if your doctor is not taking into account the length of time you've been on this medication. This isn’t a medication you should expect to get off of quickly. Although bridging may be necessary for some people personally I would never do it since I've always gone off medications extremely slowly. It's been my experience that doctors often try to reduce your medication at two quickly thereby causing withdrawal effects. I stopped some powerful medications and all without any withdrawals and and I credit doing it slowly. as the reason.
Take care,
Jake

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@julishka and @jakeduck1 I assumed a long taper. @jakeduck1 you are right about what doctors tend to suggest: "Cut in half for a week and stop.'!

Even when on an SSRI for a much shorter time, my family member needed to taper down over months, using small dose reductions and then, when at the lowest amount (I think the lowest was using liquid) doing longer time intervals between doses.

I have read that switching from a short acting SSRI to a longer acting one like Prozac can help with this but I do not remember at one point that is suggested.

@ julishka I may be misunderstanding your use of the term "bridge." I am using it as a term for concurrent meds at one point, with Prozac intersecting with the med being withdrawn, and then the Prozac being tapered. Prozac is easier to taper due to its long half life. Just wanted to be clear.

Doctors use a "bridge" blood thinner while going off and on Coumadin for surgery. I used Pepcid as a "bridge" for getting off omeprazole. In the latter case, I slowly replaced omeprazole with Pepcid and then tapered the Pepcid because it is shorter acting.

REPLY
@windyshores

I have read that Prozac is good for helping with avoiding withdrawal because it has a longer half life. I don't know if that is what is meant as a "bridge." And that may be true of Cymbalta. Does your doctor have a preference?

Personally I would prioritize minimizing withdrawal (having seen the effects in a family member) vs pain relief. Then dealing with pain after fully off. SSRI"s are supposed to help with pain receptors but not sure if that is true of Prozac (or Cymbalta) so maybe that is something to ask.

Gabapentin, in our experience, is good for neurological pain (if tolerated) and helps with anxiety.

Your doctor sounds like a good one !

Jump to this post

Thank you for your reply. I am hesitant to do the Cymbalta because as an SNRI I feel it is more of the same and I agree prioritizing withdrawal is more important.

REPLY
@jakedduck1

@julishka
I'd be curious why the doctor wants to add medication when your trying to get off it unless he's trying to stop your effexor to quickly. I'm wondering if your doctor is not taking into account the length of time you've been on this medication. This isn’t a medication you should expect to get off of quickly. Although bridging may be necessary for some people personally I would never do it since I've always gone off medications extremely slowly. It's been my experience that doctors often try to reduce your medication at two quickly thereby causing withdrawal effects. I stopped some powerful medications and all without any withdrawals and and I credit doing it slowly. as the reason.
Take care,
Jake

Jump to this post

Yes and she has done this the previous two times I tried unsuccessfully so I insisted on slow this time (I will be reducing beads by 10% per month), but I think she wants to have something in our back pocket .

REPLY
@windyshores

@julishka and @jakeduck1 I assumed a long taper. @jakeduck1 you are right about what doctors tend to suggest: "Cut in half for a week and stop.'!

Even when on an SSRI for a much shorter time, my family member needed to taper down over months, using small dose reductions and then, when at the lowest amount (I think the lowest was using liquid) doing longer time intervals between doses.

I have read that switching from a short acting SSRI to a longer acting one like Prozac can help with this but I do not remember at one point that is suggested.

@ julishka I may be misunderstanding your use of the term "bridge." I am using it as a term for concurrent meds at one point, with Prozac intersecting with the med being withdrawn, and then the Prozac being tapered. Prozac is easier to taper due to its long half life. Just wanted to be clear.

Doctors use a "bridge" blood thinner while going off and on Coumadin for surgery. I used Pepcid as a "bridge" for getting off omeprazole. In the latter case, I slowly replaced omeprazole with Pepcid and then tapered the Pepcid because it is shorter acting.

Jump to this post

Yes the bridge being when I get down to the lower dose (by reducing by 10% by counting beads) having something that will overlap and then tapering off that.

REPLY
@julishka

Yes and she has done this the previous two times I tried unsuccessfully so I insisted on slow this time (I will be reducing beads by 10% per month), but I think she wants to have something in our back pocket .

Jump to this post

Found this on ZocDoc:
"Tapering is something of a hot topic among psychiatrists, and prevailing opinion in the field is changing. For years, it’s been standard for doctors to recommend 2-4 week tapering regimens. But two psychiatric researchers recently published a paper recommending an “extended tapering regimen, reducing [a patient’s] dosage by smaller and smaller increments, down to one-fortieth of the original amount.” This method takes months or even years, but researchers say it accounts for how antidepressants change brain chemistry, while the old way does not."

I also saw reference to the fact that it can be harder to go from 2mg to 1mg than from 20mg to 10mg. In other words the end of the taper needs to go even more slowly and use a liquid.

One article mentioned that Prozac's half life is 2-4 days. Effexor is 5-10 hours. According t that article the shorter the half life, the longer the taper needs to be. One person mentioned being put on Prozac at the end of a taper of Zoloft but it wasn't clear what the timing of that was.

I am so glad to see so much more info on withdrawal online. When my family member was coming off, there wasn't much at all!

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@julishka

Yes the bridge being when I get down to the lower dose (by reducing by 10% by counting beads) having something that will overlap and then tapering off that.

Jump to this post

@julishka crossposted! Thanks for the info on how the bridge med intersects with the one you are tapering.

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