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What if this prevents cancer from becoming resistant?
I saw a thread about half-dose medications.
Guys, what do you think about whether resistance can be avoided? Read below.
Another option is to use different combinations of ADT and lutamide. For example, one month is ADT without lutamide, the second month is ADT with lutamide, the third month is lutamide without ADT, the fourth month is neither ADT nor lutamide, and then the cycle starts over again, so as not to repeat the previous cycle (the combinations would be reversed).
I had this thought, perhaps it's naive, but for some reason my intuition told me exactly this. What do you think?
In other words, varying the medications is necessary to avoid resistance. I've heard of guys who are still alive for 30 years; maybe they did exactly this?
I voiced this thought to my oncologist, and he said it wouldn't work with high Glyson levels.
At that moment, I thought about resistance as cancer adapting to low testosterone levels. The cells change and no longer respond to low testosterone.
And if you really want to "let the cancer swing," you can try to keep testosterone levels fluctuating rather than staying steady, and change the ADT + Lutamide combination depending on PSA growth. For example, if PSA growth is significant, ADT + Lutamide is taken for a month; if PSA growth is moderate, Lutamide alone is taken; if PSA growth is low, ADT alone is taken; and if PSA growth is not observed, the duration of Lutamide-only treatment is extended (2 months instead of 1 month). In any case, the method is based on the fact that we don't "create" a wall for the cancer, but rather a swing when it doesn't have time to adapt (testosterone levels fluctuate, but we don't allow it to fully utilize them with the help of lutamide).
I want to try this on myself, but fear holds me back. But who knows, maybe this method works.
Why do I think this method might work for those with a PSA level of almost 0 and whose cells have not yet become resistant to cancer?
Argument 1: If cells are still dependent on testosterone, they will respond to ADT and lutamide when drug therapy is resumed.
Argument 2: By changing combinations and increasing testosterone levels, we prevent cancer from becoming resistant because we are changing the "rules of the game" and not dealing with cells that are no longer responsive to ADT and lutamide.
Argument 3: By repeating combinations in a cycle (ADT and lutamide, ADT only, lutamide only), we maintain a basic level of protection by closely monitoring PSA levels, which is an indicator that resistance is not developing.
Argument 4: Cancer has little time to "start firing." A new combination will either lower testosterone (ADT) or dampen the ignition.
Argument 5: It's no secret that they're making money off us, and the higher the stage, the more money they make. But they can make much more money if resistance develops (medicine is a business), and perhaps that's why ADT and lutamide inevitably lead to the development of resistance! What if we take our luck by the balls and say no to a society in which someone profits by keeping silent about the easy way out (when registration doesn't occur)
And finally, if the cancer becomes resistant, then we're done for, and we need to avoid it at all costs to keep the cells sensitive to hormones.
What do you think, guys? Is it risky?
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@stage4lovolmetpc
A number of people over at ancan.org Advanced prostate cancer weekly meetings, have stopped ADT and are only on Nubeqa. It works quite well for all of them. Not saying it’ll work forever, but that’s what we live with. You eventually get resistance. You could attend one of the weekly meetings and see what people have to say.
One guy who was in a bimonthly CSC group, I was attending switched to Nubeqa After I recommended it during one of groove, meetings. He moved to South Africa so he is no longer able to attend the meetings, but he sent me a private message on the Healthunlocked forum saying he switched to Nubeqa alone, he’s 80, And his PSA’s been staying Undetectable for quite a many months. He’s real pleased with his results.
It might’ve worked for you. I do know that in my case, my oncologist does not want me to stop Orgovyx Because I have BRCA2 and my cancer could come back sooner,even though I am on Nubeq. I did stop Orgovyx For eight months and my PSA stayed undetectable with just Nubeqa, But my testosterone rose too quickly, and my doctor wanted to be back on it.
Just some experiences, other people have had with Nubeqa.
@jeffmarc
Thank you Jeff for your insight re my comment and I also want to thank you for the HealthUnlocked referral...I have enjoyed reading there and that forum has led to several others as I spin down the prostate cancer rabbit hole...lol...but now its time to get outside and get busy: mowing, chainsawing, trail clearing, running the dogs, fixing equipment, always something here in the woods that needs to be clipped, trimmed, picked up, put down, moved around....
Who has time to worry about PCa.....laughing at myself....I might be terminal but Im going to keep on keeping on...hey!.... Was that a Furry Freak Brothers reference? Keep on Trucking? Guess the brain fog is kicking in...help me out here...
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1 Reaction@stage4lovolmetpc
Mr Natural!
@northoftheborder
Oh yes, both articles are actually in context of future "personalized" approach to each case.
New research concentrates on discovering WHY some patients get to the point of resistance and why some can be on ADT for years without developing resistance. They discovered that there are different ways of how cells develop resistance since cells can have different mutations with the same end result - not having apoptosis and multiplying fast. That is why single approach can NOT be the answer. There will never be "one silver bullet" that would cover all patients especially in advanced cases.
I sent you those links since you like to read and analyze new research papers ; ), not necessarily thinking that they apply to your particular case - the point was that there is new research that is based on individualization of treatment for metastatic patients depending of the mutations that they poses.
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1 Reaction@jeffmarc Thanks. however, could there be a reason to take a full dose when half a dose seems to have done its job by keeping my PSA at undetectable?
@stage4lovolmetpc Thanks for your feedback. I’ve been planning a convincing presentation to my oncologist to either stop taking both after the one year anniversary, or as a fall back stop the orgovyx only. I truly dislike seeing my body turn into the Pillsbury doughboy despite going to the gym 4x/week for a full year. Or is it the Michelin Tire man I’m turning into?
@lsk1000
I can only imagine the problem could be that you could become resistant to the low level of the drug sooner than if you took the full dose. When I cut back on abiraterone dose from 4 pills to threeMy PSA started rising immediately. Within 18 days it Rose from .2 to 1. I went back on the full dose and my PSA went back down to undetectable. I was castrate resistant to ADT, however so it alone would not work.
You might ask the doctor about this.
If you are still on ADT and have not become castrate resistant to it then the amount of drug you take is really not that relevant since the ADT alone will keep your PSA undetectable.