Weight Gain From Zoloft

Posted by merman2222 @merman2222, Jun 6, 2023

Hi,

This is for anyone else experiencing weight gain while on SSRIs. I really want to get to the bottom of this so any info would be greatly appreciated. I started this med when I was in my late 20s and my weight literally changed overnight. I went from 168 lbs, which I maintained for years prior regardless of how much I ate, to almost 200 in less than a month. At first I was thrilled, because I had been trying to put some meat on for years. That didn't last long once I realized how hard it would be to take the weight off. It's nearly impossible.

Before anyone says anything about diet and exercise, let me preface this by saying neither changed before or after I started taking this, nor did my sleeping habits. I have been an athlete all my adult life. I run and/or lift weights approximately 2-3 hours a day, every day, plus swim and practice jiu jitsu (which in my class is an hour of intense cardio). As for my diet, it was pretty much the classic "american" diet before and after - meat and potatoes, with fruits and vegetables mixed in and something sugary for dessert after dinner. Again, before the med, no weight gain. After, massive weight gain.

As for metabolism slowing down as you age, I got off of this med several times trying to find an alternative. Unfortunately, nothing worked so I ended up getting back on it. However, WHILE I was off of it, my weight quickly normalized. So it's definitely the medicine that is causing this.

I tried for years to pinpoint EXACTLY what was happening in my body and experimented on myself many times. I came to the conclusion that it is fluid weight and that it is either caused or exacerbated by refined sugar (natural sugar or Stevia is okay). If I eat anything with refined sugar, my weight jumps up drastically in a very short time.

So the only solution I derived is to stay on a very restrictive diet, like keto, because pretty much everything has sugar in it these days. If I do that, my weight is manageable, but it also makes for a miserable life because I can't enjoy food (and the keto versions of bread etc don't taste nearly as good as the real thing).

I did an experiment recently where I weighted myself after a week of healthy eating, then again after eating some KFC, and I recorded both weigh-ins. Before the KFC, I was 188. Afterwards, less than an hour later, I was 194. That's a six pound gain from one meal. And that's not even the worst example. I once gained 11 lbs from eating a slice of white bread.

I guess I am not looking for dietary recommendations so much as I am trying to figure out what is going on in my body. I would like to get checked out over an extended period of time while I eat different things to see how my body reacts to it. Like, put some sensors on me and have a doctor monitor my internal organs and glands to see what biological reactions occur. Is there such a clinic or lab that can accommodate that?

Because all the info I find online basically says doctors don't know exactly why these meds cause weight gain. That's not good enough for me. I need to know a little more and I'm sure others would appreciate that info as well.

Interested in more discussions like this? Go to the Digestive Health Support Group.

Is there any way to curtail the weight gain with Zoloft? So far, it's the best antidepressant that has worked for me, but I gained 5 lbs the first week on was on it!

REPLY
Profile picture for pljauthor @pljauthor

Is there any way to curtail the weight gain with Zoloft? So far, it's the best antidepressant that has worked for me, but I gained 5 lbs the first week on was on it!

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I could be water weight? I haven’t had that issue. Maybe if you take with food and drink 20 ounces of water with it?

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Profile picture for pljauthor @pljauthor

Is there any way to curtail the weight gain with Zoloft? So far, it's the best antidepressant that has worked for me, but I gained 5 lbs the first week on was on it!

Jump to this post

I gained weight while on Zoloft, too, so you are not alone! Maybe try more physical activity? Just an idea. I think the Zoloft slowed all of my metabolism.

Last year I went to a nutritionist who pointed out that eating at night can add pounds. I took that advice and lost some weight and kept most of it off. I eat dinner earlier and in the evenings I drink water or decaf tea or a big glass of low fat milk.
Good luck to you 🙂

REPLY
Profile picture for pljauthor @pljauthor

Is there any way to curtail the weight gain with Zoloft? So far, it's the best antidepressant that has worked for me, but I gained 5 lbs the first week on was on it!

Jump to this post

Sounds like great advice! I'll give it a try.

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Profile picture for elke1211 @elke1211

I could be water weight? I haven’t had that issue. Maybe if you take with food and drink 20 ounces of water with it?

Jump to this post

Zoloft i think lists as known side effects “weight gain”. It totally established my “set point” and i’m still trying to lose the 10–15 pounds i gained ff
taking zoloft. Im also trying to get my pre-diabetes condition that suddenly emerged —1under control. I wish would have talked to my dr sooner about taking me off zoloft. I have never had a problem with water weight unless i eat chinese food

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Profile picture for annewoodmayo @annewoodmayo

I gained weight while on Zoloft, too, so you are not alone! Maybe try more physical activity? Just an idea. I think the Zoloft slowed all of my metabolism.

Last year I went to a nutritionist who pointed out that eating at night can add pounds. I took that advice and lost some weight and kept most of it off. I eat dinner earlier and in the evenings I drink water or decaf tea or a big glass of low fat milk.
Good luck to you 🙂

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why not consider talking to your dr about a substitute drug that doesn’t have known adverse effect of weight gain?

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Profile picture for elisabeth007 @elisabeth007

why not consider talking to your dr about a substitute drug that doesn’t have known adverse effect of weight gain?

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You are right. It’s not all that common to gain on SSRI meds. I believe 1-6% is the average in those prone. (Directly and indirectly from the medication). As a psych professional I haven seen as much as with anti psychotics which can be 10-50 pounds on average. Wellbutrin is thought to cause least chance of weight gain. Everyone is different though, you’re right. Could try a different SSRI like Prozac or SNRI like viibryd. Talk to doc. It could be life style issue like sleep, exercise, feeling hungry when not depressed. The body is a mysterious entity.

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Profile picture for annewoodmayo @annewoodmayo

I gained weight while on Zoloft, too, so you are not alone! Maybe try more physical activity? Just an idea. I think the Zoloft slowed all of my metabolism.

Last year I went to a nutritionist who pointed out that eating at night can add pounds. I took that advice and lost some weight and kept most of it off. I eat dinner earlier and in the evenings I drink water or decaf tea or a big glass of low fat milk.
Good luck to you 🙂

Jump to this post

I was hungry at night from not sleeping so much

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Profile picture for elisabeth007 @elisabeth007

Zoloft i think lists as known side effects “weight gain”. It totally established my “set point” and i’m still trying to lose the 10–15 pounds i gained ff
taking zoloft. Im also trying to get my pre-diabetes condition that suddenly emerged —1under control. I wish would have talked to my dr sooner about taking me off zoloft. I have never had a problem with water weight unless i eat chinese food

Jump to this post

Psych meds often list raise in blood sugar as a side effect possible. Exercise physically can lower blood glucose without as much cellular activity involved in that act. Antipsychotics are the greatest offender, but it’s a side effect of many meds. Great point.

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Profile picture for elisabeth007 @elisabeth007

why not consider talking to your dr about a substitute drug that doesn’t have known adverse effect of weight gain?

Jump to this post

Moving to another drug--Trintellex--these past two weeks. Already losing weight!

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