Very tender/sore testicles

I'm 13 months into the same package of medication and have a similar scenario that occurs occasionally. I try to play nice with the testicles with gentle cleaning and gentle placement, as opposed to how I've lived my life up to this point. For me it started about 1 month ago, and will share this finding with my oncologist in early January. Generally speaking, there is quite a bit of quality of life issues that comes with ADT, but if it keeps my PSA less than 0.1, I'm cool with it.

Thankyou for your reply. I thought it was just me. Also will bring up with oncologist next visit months away. I'm on the same page as you, adt sucks, but I'm adjusting well to side effects and extremely appreciatively for my continued survival....stage 3b, gleason 8....very high risk rating. Best to you!

I had a radical prostatectomy 20 months ago. After the operation my left testicle felt "strange" odd tingling and sometimes stabs of pain during the night. My urologist told me it would settle down in a month, but it did not. The tingling disappeared but the night pain continued on and off. My testosterone levels fell and I went on HRT to help stop night sweats. I had ultrasound scans of the testicle but it did not show anything significant. The pain continued causing interrupted sleep at night, I tried antibiotics but they did not work, the only thing that helped was paracetamol. After 12 months I had another ultrasound and the testicle had shrunk 50% from its original size and it felt very soft. My urologist told me the testicle had basically stopped working. Out of frustration, I had the testicle removed 9 weeks ago. I am aware that after a prostatectomy testosterone levels can fall but usually recover. Mine did not and I am now permanently on HRT, Could anything else have been done?

@john1951 Sorry for your very painful result. The only thing that makes some sense to me is that blood supply or innervation to the testicle was somehow compromised during the surgery.
Something could have been nicked, jostled or traumatized in a way that barred its recovery.
You don’t mention full blown necrosis of the testicle, so some blood supply was maintained. But the ‘normal’ procedure usually has no direct bearing on the testicles themselves.
I have a varicocoele in my right testicle and even that did not change for better or worse after my surgery. Best,
Phil

Will follow this with interest. I have the same symptoms as the OP although it sounds like his are more severe. I had 20 rounds of radiation in May. I am on Orgovyx and Xtandi since March. I am a Gleason 8 Stage 4 low volume. The tenderness started about a month ago. Plan to bring it up with my Urologist when I see him in early February.

Is there any swelling? Does the pain get worse when you feel it?

Testicular atrophy?

I've been having pain lately too (ADT for 1.5 years, Erleada for 9 months). It started hurting after I started moving less. It could be a circulatory problem.

Try moving more, walking, and doing squats to increase blood flow in your pelvis. I do 30 squats every hour, which works out to about 360 a day, but I think that's not enough and I should increase that number to 1000 a day.