Tips on minimizing withdrawal symptoms from Effexor (aka Venlafaxine)

Posted by richyrich @richyrich, Nov 2, 2016

I have been taking Effexor/Venlafaxine for years and tried to get off it a few times but each time I try to give up the chemical withdrawal symptoms are a horror story and I give up giving up. Anyone got any tips or tried and tested strategies? Thank you

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Profile picture for linxy @linxy

I went off Venlafaxine 4 weeks ago after being on it for several years. I tapered down from 225 to 75 myself, it was really ok. But i couldn't get down to 37.5 without getting brain zaps, nausea, headaches, insomnia, trembling, anxiety and all the rest. I went to see a psychiatrist who booked me into hospital for a couple of days to help me get off and to monitor me. For the first 2 days he put me on 37.5, then and from day 3 nothing. From day 1 though he put me on Urbanol that helped with anxiety, Aropax SR 25 mg, pain meds and nausea meds as necessary, Biotrazadone 100mg at night, Disipal that helped with the brainzaps and shaking and Inderal. Using those meds really helped a lot, i only experienced slight brain zaps, a little bit of nausea, diarrhea and vertigo, nothing as severe as when i tried to go of Venlafaxine by myself. Im off it now and adter a month i only get slight brain zaps occasionally, feeling a little weak and tired but nothing too bad. I could stop using Disipal, Inderal, pain and nausea meds.

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May I ask what you replaced it with ?

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Profile picture for tammy1016 @tammy1016

May I ask what you replaced it with ?

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Hi there. I am now on Aropax and Azor. I hope it helps.

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Profile picture for nananancy @nananancy

My goodness~ your taper is by far the quickest I have read about.
I am 63 - been on anti depressants for about 30 years. Initially started after a difficult child birth, a big company move shortly after. . I started off with Prozac - it saved me. I had developed agoraphobia . I thought I must have a brain tumor! Not much was written about it back in the day. But I was handed the book (by a stranger in a library ) (“Peace from nervous suffering” written by Claire Weeks. This was a Godsend. It was like it was written personally for me! I was not going crazy - !!! I have a chance. Eventually Prozac stopped working and went to a few different ones after that. Since 2021 I have been tapering off of Effexor. It stopped working for me once I was in full menopause. (2 years ago) I had no joy. I’ve been slowly eliminating it out of my system over a year and a half. 225mg- 150 (hardest taper..struggled..my darkest time). I felt like I was dying. Darkest thoughts. Paralyzing fear. With all the strength I had, I put my self into a 36 day TMS regiment. Just getting out of bed everyday and showing up an huge achievement. I started to feeling a positive shift after my 17th appt. - I was showering every day and running occasional errands. For a full month after - I felt normal. Energized, calm, participating in life, patient, engaging…best feeling in life. Is this what life is suppose to be like? After 40 days- the magic left me. I was devastated. One month passed and I decided to put my self back in to TMS but for only 3 days a week. I just started- so I will keep you posted. I am now on 75+37 1/2 mg …feel nauseous and have a lot of brushing sounds in my head. .. . I will eventually go to 75mg —anxiety is so debilitating to me.
They are not recommending Xanax..because the new studies are they are linked now to Alzheimer’s (besides being addictive) My pcp won’t prescribe them anymore. Paxil is out of the question because like Effexor…it’s another drug that’s a struggle to get off of. If I miss just 1 dose of Effexor, I can’t even walk without holding on to a wall! I can’t turn my head with out electrical shocks. Some shocks are so explosive and loud that it’s frightening. It’s like someone shutting off the power grid for a whole skyscraper. . I often feel like In have the flu. The sweeping and zaps are ridiculous. Big Pharma took their first Effexor pill off the market for a reason. I’ll never understand why this XR is even on the market. To me it’s a poison. I’ve been in anti-depressants for at least 30 years.
Anytime I mentioned i was feeling blue or having anxiety - my pcp’s just assumed my meds stopped working and changed them. It’s very frustrating.
Now I am experiencing restless leg/body syndrome- my body just jolts off the bed while trying to sleep. I am for medication if it works and has little side effects. Effexor is the devil. I’m sorry to all of you in this struggle. I will keep you in my thoughts. I’m rooting for all- N

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Most current study shows benzodiazepines are not linked to Alzheimer’s.

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Profile picture for dor123 @dor123

This has been hell. Was off for seven weeks but my body and mind couldn’t do it anymore. Was pure hell. Anyone else experience this horror.

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I have been travelling for the last three days and accidentally forgot to take my medication for that amount of time. I woke up this morning very disoriented and dizzy. I took my pills as soon as I realized what was going on. Does anyone have any advice? I'm not trying to stop taking my medication, so many of the other threads don't apply to me. I have felt feverish all morning (checked temp, its 99) and I've been drinking a lot of water and have tried eating when I can. Is this a "just wait it out" scenario?

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Profile picture for mrwakefield @mrwakefield

I have been travelling for the last three days and accidentally forgot to take my medication for that amount of time. I woke up this morning very disoriented and dizzy. I took my pills as soon as I realized what was going on. Does anyone have any advice? I'm not trying to stop taking my medication, so many of the other threads don't apply to me. I have felt feverish all morning (checked temp, its 99) and I've been drinking a lot of water and have tried eating when I can. Is this a "just wait it out" scenario?

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You should be okay shortly.

Venlafaxine has a very short half-life, about six hours. Within 24 hours, all that's left in your system is about 6% of the initial dose, hence the quick onset of discontinuation effects.

I don't know how long you've been on this medication or the dose you are taking, but I was on 450mg a day for fifteen years. The effects on cognition destroyed my life, and the side effects led to all kinds of health problems, causing my doctors to prescribe more and more medications.

I have been titrating this medication under my provider's supervision for a year and still have to take 112.5 mg daily to avoid discontinuation effects. I expect it will take another year to get off of it, as I will be decreasing it to only 5mg at a time in the future. I needed a compounding pharmacy to make the pills.

The only reason the dosing is the way it is—minimum 37.5mg—is profit. Pharmaceutical companies can not make money if they do it more accurately. I'm not making this up; it is the only reason. They know that suffering could be reduced by having more dosing options; it's just not profitable.

They also knew about the discontinuation effects from the get-go but buried them with the help of AMA, yeah, for real.

The science is clear: The overwhelming benefit of this medication is the placebo effect, which is real. The remainder is due to its emotional blunting; one is not less depressed; we just feel less overall. That, in and of itself, can sometimes be a blessing.

Nonetheless, this is part of a class of medicine science that proved ineffective over a decade ago. It typically takes 17 years before the medical establishment embraces new information, and you can blame Big Pharma for that.

You should be feeling better by the time you read this.

Good luck with whatever trauma you are dealing with that necessitated the prescription of this poison.

I hope you live in peace and good health.

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I have been taking Effexor for 4 years. I am now at my lowest 37.5. I had to cold turkey stop on all medication’s for a surgery. I’m on day three Without it and these are the symptoms I’m experiencing. Anxiety,low energy,depression. I feel like I’m about to cry, but I don’t quite do it. My head is about to explode The brains zaps are terrible. Just getting out of bed is exhausting. My surgeries in two days after that, I’m hoping I could come back on it because I am miserable, irritable. Because I’m getting surgery, I can’t take anything else to help. Just been resting And avoiding people so I don’t snap at anyone. It’s pretty bad. I don’t even know myself without this medication. I knew it helped, but I didn’t think it helped to this extreme. I’m hoping the next two days are a little better. Forcing myself to eat and hydrate. Trying to get through this.

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Profile picture for tammy1016 @tammy1016

May I ask what you replaced it with ?

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What is brain zaps?

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Profile picture for looplu79 @looplu79

What is brain zaps?

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Like electrical currents running through your head. Fun.

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Profile picture for mrwakefield @mrwakefield

I have been travelling for the last three days and accidentally forgot to take my medication for that amount of time. I woke up this morning very disoriented and dizzy. I took my pills as soon as I realized what was going on. Does anyone have any advice? I'm not trying to stop taking my medication, so many of the other threads don't apply to me. I have felt feverish all morning (checked temp, its 99) and I've been drinking a lot of water and have tried eating when I can. Is this a "just wait it out" scenario?

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Thank you

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I’m down to opening the capsule and taking 1/5th each night to minimize the side effects. I titrate off EXTREMELY slowly! Be prepared for your doctor to look at you like you’re nuts, but whatever it takes and they need to know that some of use are very very sensitive to drugs.

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