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Urologist said I could stop Orgovyx. Your thoughts?
Age 73, in very good health. Diagnosed with Gleason 9, August 2024. Been taking Orgovyx since then, Not quite 20 months. Completed 28 sessions of IMRT April 2025. Latest lab results a few weeks ago: PSA < .04, testosterone < 1. My urologist said I could go off Orgovyx when my medication runs out in 15 days. I’m somewhat hesitant to do so because who knows how my PSA and testosterone levels will be affected. Thanks for any feedback, thoughts, etc.
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Intermittent therapy and watchful waiting often work well. The exact science on it is still developing, and what is appropriate depends on initial severity, but for many common cases it looks to me like in the future the initial treatment periods will be shorter. There is variation between people and over time so you track your PSA and T. Exactly what levels are OK may also be refined over time, but with treatment suspended many people seem to maintain quite low numbers for years. This is good - this is what effective treatment should do! Perhaps additional treatments will also be developed to monitor more effectively, be even more accurate than just PSA and T numbers, "precision medicine" is a big trend today for just these kinds of treatments and measurements.
It may even be that more normal intervals help with maintaining overall health and longevity.
@jeffmarc
I suggested that to my RO who said it was better to wait 6 months. The reason was that if the result was favorable - i.e. low psa - it could have been caused by residual Orgovyx in my system. He wanted me to wait 6 months before another psa test.