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Update on post Evenity treatment
I finished a year of Evenity in June 2024. I started Prolia the end of August. I would have started sooner except that I moved and had to find a new provider, had delays with them getting prior authorization for the Prolia ( I had to call daily for over a week to get them to finally take care of it). I have had 2 injections so far. Evenity had amazing results for my spine (-4.6 to -3.0) and slight gains in my hips. My endo said Prolia could potentially give me further gains and reduce fracture risk. Tuesday I had a DEXA scan, just over a year from my last. I was really hoping for more improvement in my spine, as I have had 5 mild fractures over the years. Very disappointed that it’s now -3.2, so went in the wrong direction there. My hip scores did improve and are now osteopenia, and my fracture risk lowered by one digit. I’m wondering if Evenity is a one time thing or can be done again. My copays were outrageously expensive but I’m applying for financial aid and would do Evenity again if I could.
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My doctor just suggested Evenity and I'm beginning my research on it since it's rather new. The side effects of stroke and heart issues are concerning. Thank you for the hopeful comment.
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5 ReactionsThat was a good response from Evenity. I am unsure if anyone is receiving a second treatment. I couldn't find any clinical studies on that. I am sure doctors must be considering it, though they might not want to proceed without evidence that a second round of treatment is advantageous.
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3 ReactionsHubby has had several Evenity injections. No problems.
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1 ReactionNo quite the second treatment you are envisioning but taking it for 2 years consecutively.
Effects of 24 Months of Treatment With Romosozumab Followed by 12 Months of Denosumab or Placebo in Postmenopausal Women With Low Bone Mineral Density: A Randomized, Double‐Blind, Phase 2, Parallel Group Study
Michael R McClung, Jacques P Brown, Adolfo Diez‐Perez, Heinrich Resch, John Caminis, Paul Meisner, Michael A Bolognese, Stefan Goemaere, Henry G Bone, Jose R Zanchetta ... Show moreAuthor Notes
Journal of Bone and Mineral Research, Volume 33, Issue 8, 1 August 2018, Pages 1397–1406, https://doi.org/10.1002/jbmr.3452
Published: 25 April 2018
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2 ReactionsMy only side effects were sore arms that would start a few hours after the injections and last until the next day. That got less bad after the first few injections.
@andersdarc Hi. I completed a year of Evenity and had no side effects whatsoever and experienced excellent gains. Best wishes to you moving forward.
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2 ReactionsThere is a discussion about the doing a second year of Evenity on Inspire.
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/b7bb19-anyone-done-a-second-year-of-evenity-after-a-2-yr-break/
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2 ReactionsMy Dr wants me to consider Evenity. I am also approaching a hip replacement. Has anyone had this operation while taking Evenity?
Thank you! One commenter pointed out that insurance might not cover a second round, if that was the case I could never afford it. I will definitely mention the study to my endocrinologist though.
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1 ReactionThere are two small studies supporting using Evenity beyond a year and or repeating Evenity. My doctor has a small number of patients doing that and I intend to do that also after a year or so off of Evenity. I'm using monthly Risedronate in the interim. Insurance and money are issues unfortunately, but I hope to manage that somehow. My doc also suggested just using it for 6 months next time saying there was a Korean study that showed that you got most of the results from Evenity in 6 months. I intend to do whatever I have to do to have another round and get more gains in density.
As anecdotal evidence for Evenity I took a wrong turn in the dark recently and fell wildly down our basement stairs. I wrenched my foot and knee but broke nothing. That was quite an experience. Of course I don't know for sure what would have happened if my spine still had vertebra lower that -4.0, but I'm definitely glad I had all the density improvements from Evenity before I took that tumble.
BTW, I participated in that Inspire discussion that @19kcm56 mentioned. I'll post what I said there here:
"I found two relevant articles. In one they did two years of Evenity consecutively and in one they did a year of Evenity, then a gap of nothing and then another year of Evenity. There are other things going on in both these studies so you have to find the particulars of interest to you but both are highly relevant and encouraging.
In the first study there was continued benefit for the second year even though everyone says you can only take it for one year. The benefits did slow down but did not stop. No extra safety concerns found for second year.
In the second study more relevant to your situation the second year of Evenity following a 1 year gap was almost exactly as effective as the first. That one says no new safety concerns in second year.
The two years consecutive study:
https://pubmed.ncbi.nlm.nih.gov/29694685/
The 1 year, gap and then another years study:
https://link.springer.com/article/10.1007/s00198-019-05146-9
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Best of luck to you
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