Unable to find recommended dose of AREADS 2 vitamins

Posted by bimbra @bimbra, Nov 3 2:08pm

I was advised to purchase over the counter vitamins AREAD 2.
After searching the internet I have yet to find a brand which matches the recommended dose:
Research from the Age-Related Eye Disease Study 2 (AREDS2) has shown benefit in a formulation that includes:
500 milligrams (mg) of vitamin C.
400 international units (IU) of vitamin E.
10 mg of lutein.
2 mg of zeaxanthin.
80 mg of zinc (as zinc oxide).
2 mg of copper (as cupric oxide).
= = =
Is there a brand which is available that meets the recommended dose?

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Be cautious if you find a formulation like you listed. The 80 mg of zinc is too much for a lot of people and will cause digestive issues. The upper limit for zinc consumption in a day is 40mg and can inhibit the absorption of copper. Copper depletion can cause many issues like changes in your red blood cell count, balance, memory, anemia, and heart issues. Here is one that has all the components and has been lab tested:
https://www.viteyes.com/product/viteyes-classic-areds-2-capsules
If you want to forgo the zinc and copper and stick with the lutein and zeaxanthin formulation this supplement has been lab tested:
https://www.iherb.com/pr/life-extension-macuguard-ocular-support-with-saffron-60-softgels/69065

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Beebe, thanks for taking time to respond. I'll review the links. Tosh.

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Its on the back of the box! Read

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@beebe

Be cautious if you find a formulation like you listed. The 80 mg of zinc is too much for a lot of people and will cause digestive issues. The upper limit for zinc consumption in a day is 40mg and can inhibit the absorption of copper. Copper depletion can cause many issues like changes in your red blood cell count, balance, memory, anemia, and heart issues. Here is one that has all the components and has been lab tested:
https://www.viteyes.com/product/viteyes-classic-areds-2-capsules
If you want to forgo the zinc and copper and stick with the lutein and zeaxanthin formulation this supplement has been lab tested:
https://www.iherb.com/pr/life-extension-macuguard-ocular-support-with-saffron-60-softgels/69065

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I came here to say exactly the same thing. 80 mg. If zinc is FAR too much.

Here’s some info on zinc dosage and dangers of overdosing. https://www.mayoclinic.org/drugs-supplements-zinc/art-20366112

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What is most puzzling is that the research from the Age-Related Eye Disease Study 2 (AREDS2) is what is mentioning the formulation. Is that research wrong?

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I don’t have a medical degree, but in my (informed) opinion, yes, the study is wrong.

There’s another thread on this forum (link below), in which several people, including me, tell of their experience with AREDS (Preservision specifically). I recommend reading through the whole thread. https://connect.mayoclinic.org/discussion/areds/

In my posts, I include this article I found that pretty much explains why the studies are wrong. Here’s a link to that if you don’t want to read thru the other thread.
https://www.cureamd.org/best-eye-vitamins-macular-degeneration/

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Bimbra, The results of the AREDS2 study needs to be delved into to find your answer. The AREDS2 study was designed to look at replacing beto-carotene with lutein/zeaxanthin as the beto-carotene was found to contribute to lung cancer.

This analysis of the AREDS2 study revealed the benefits of the high zinc(80mg) vs lower dose of zinc (25mg) supplementation. Basically it says there was no difference. Since too much zinc carries risk with it why take it if it does not have a greater benefit?
FROM THE ANALYSIS:
"WHAT IS THE BASIS FOR THE CONCENTRATION OF ZINC IN THE AREDS SUPPLEMENTS? WHAT CONCENTRATION SHOULD I TAKE?
In the AREDS trial, the 80 mg zinc dose (alone or in combination with antioxidant vitamins) was found to be effective compared to a placebo. Although zinc was found to be an essential component of the AREDS formulation, some nutritional experts recommended a lower dose. In the AREDS2 trial, there was no placebo control. Instead, participants were given the option to take the original formula or to be randomly assigned to receive a modified version, such as a formula containing 25 mg zinc. THE INVESTIGATORS DID NOT FIND A DIFFERENCE IN THE EFFECTS OF 80 MG VS. 25 MG ZINC. Because AREDS2 did not include a placebo control, results from AREDS, placebo-controlled trial, are still considered the gold standard."
https://www.nei.nih.gov/research/clinical-trials/age-related-eye-disease-studies-aredsareds2/aredsareds2-frequently-asked-questions

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