Anyone have experience with Triple (Triplet) Therapy?

I'm also the wife of a wonderful man with Stage 4 HS metastatic PC on ADT, and just started Darolutimide yesterday. ADT dropped from 500 (!) to 150 in 3 weeks, but WBC and Ferritin are low. We will be starting chemo hopefully in August, only if my husband's WBC improves. It's all so terrifying. Our doctor looked us straight in the eye for our prognosis and said "five years is the median". I almost fainted. It's so hard to know what's next and navigate so much information and "what ifs". Looks like you're Canadian, too! We're in Winnipeg.

@kerryfr
Nobody knows I have prostate cancer Unless I tell them. I never got fatigue from ADT.

I do go to the gym three days a week to keep my muscles from getting weaker, I walk a mile twice a day on a track to keep in shape. I’ve been taking bone straighteners for almost 8 years to offset the effects of bone weakening.

I’m 78 years old and people tell me they think I’m 68 if they don’t know my age. The people I see at the track and gym can’t believe how old I am, since I can do the exercises I do.

I’ve had surgery twice in the last nine months and have recovered very quickly. A month ago when I was in the recovery room, the nurse said I woke up and recovered much quicker than most people.

Everybody reacts differently to prostate cancer. I have the genetic problem of BRCA2, which makes my cancer much more aggressive. That’s why it has come back four times. The drugs just keep getting better.

@jeffmarc You're right -- I made an error -- PSA was 500. It's so wonderful to hear stories like yours. Do you feel well? Or does the treatment over many years take its toll?

@kerryfr
Median survival means various things. You said ADT dropped, but I know you meant PSA dropped.

In 2019 I became castrate resistant. Median survival was 2 years.

I was on Casodex and abiraterone the first 4 years, And my PSA was only undetectable one month.

I switched to Orgovyx for ADT and Darolutamide. Had a metastasis on my spine zapped 3 years ago. It’s now 2026 and I’ve been undetectable for more than 2 1/2 years. It could come back, but it’s been almost 7 years since my two year median survival date.

New drugs keep coming out and your husband may get the benefit of more than Darolutamide. Hopefully his PSA will drop down considerably from where it is now with Daro.

Prostate cancer is a chronic disease for most of us, Not a deadly disease.

I'm also the wife of a wonderful man with Stage 4 HS metastatic PC on ADT, and just started Darolutimide yesterday. ADT dropped from 500 (!) to 150 in 3 weeks, but WBC and Ferritin are low. We will be starting chemo hopefully in August, only if my husband's WBC improves. It's all so terrifying. Our doctor looked us straight in the eye for our prognosis and said "five years is the median". I almost fainted. It's so hard to know what's next and navigate so much information and "what ifs". Looks like you're Canadian, too! We're in Winnipeg.

Triple therapy done, with hubby’s last chemo treatment 4 weeks ago!
He tolerated the treatments reasonably well, all things considered.
His first follow up was today, and the oncologist is pleased. Hubby is now on maintenance with the Orgovyx (Relugolyx) and the Darolutamide. He has follow up scans in July.

So thankful for his medical team and science.

His PSA went from 990.39 to 5.24 and could still drop. His scans show good results too.

He is feeling frustrated that he is still feeling fatigued and not able to do everything, but knows it can take months… and is a far cry from where he was in January!!

The support on the forums here has been helpful too and I thank you all.

@canadaanne Now that they've seen why people get taken ahead of them, my family members don't resent that they sometimes have to wait 4–6+ hours after triage to be seen by a resident in the ER (e.g. for a possible fracture or a light concussion), when I have to wait only a few minutes.

When you have stage 4 cancer (and a history of DVT and serious spinal injury in my case), it's good that there are *some* benefits, however meagre.