Pancreatic Cancer Trials that look promising

Welcome, @askretka. Do you have pancreatic cancer? Are you looking into clinical trials?

Looks like a very small evaluation with just 3 patients. While interesting, I gather it is a very long way from Phase 1/2 clinical trials?

It's a Phase I/2 Trial. It will now move to 12 patients.

Pelareorep a natural virus has been proven safe in over 1000 patients now.

P3 Breast cancer trial with Pfizer possibly next year. They are hoping to piggyback off that and take to a P3 Pancreatic trial. All depends on next 9 patients I guess.

Don't have cancer doing some research for someone else.
The Oncolytics/Roche trial is only a 3 patient safety trial that will now be expanded to 12 patients. Was newest and best I could find. It's very early though.

New promising Treatment from Phase I/II GOBLET study

Oncolytics Presents Promising Pancreatic Cancer Data at SITC https://www.biospace.com/article/following-promising-data-oncolytics-plans-to-move-pancreatic-cancer-therapeutic-into-phase-iii/

KOL today on Promising new Pancreatic cancer treatment
https://lifesci.rampard.com/WebcastingAppv5/Events/eventsDispatcher.jsp?Y2lk=MjA1Mg==

Hi @askretka, I see that you continue to research promising pancreatic cancer trials for your friend or family member. I moved the new discussions into one thread called:
– Pancreatic Cancer Trials that look promising https://connect.mayoclinic.org/discussion/trial-in-germany-looks-promising/

I think your research in one place will be helpful to members. 🙂

Thanks. Small trial 13 patients but looks promising for future possibly. They are have no trouble filling these trials unfortunately or fortunately I guess for those that can get in. My relative/ friend is pallative now.

Results look promising experts interviewed say it warrants going to a P2/P3 trial.
————————————-
November 10, 2022
One complete response (CR) and eight partial responses (PR) achieved in thirteen evaluable patients

69% objective response rate (ORR) is nearly three times greater than the average ORR of ~25% reported in historical control trials

clinical trials.gov has the approved trials and a list of inclusions and exclusions.

I am looking at clinical trials but nothing so far that I will qualify for.

Finding a clinical trial can be a daunting task requiring perseverance. Precision Medicine (molecular profiling by Next Generation Sequencing [NGS] and liquid biopsies) to reveal possible gene mutations driving the cancer helps in narrowing the focus for using Targeted Therapy directed at the mutation. Even with that info, searches can be daunting reading through the scope of the trial and the inclusion/exclusion criteria.

Besides clinicaltrials.org, PanCan.org has a search page and case managers you can call (877.272.6226, M-F, 7:00am-5:00pm PT) that work with staff at CancerCommons.org to do the time consuming work in narrowing down the list of potential trials. LetsWinPC.org partners with EmergingMed.com that also has a staff you can speak with to get more clarification of a specific trial. myTomorrows.com is another clinical trial finder service and the staff takes it a step further- they will help with the enrollment process making the phone calls to principal investigator/ clinical trial nurse coordinator so everything is done and a potential participant just needs have an eligibility exam and to read through and give informed consent. All the services through the above search firms are free of charge.

From personal experience, I had molecular profiling done early on. That allowed me to focus my search. Still it took 14 months to find the perfect fit between between aspects of my case and the trial. I searched clinicaltrials.gov and PanCan.org weekly. As a former cancer researcher, I also was perusing the American Society of Clinical Oncology website one weekend as their annual meeting was underway. I saw an abstract just posted of a “proof of concept” trial detailing the results of the two participants. The abstract hinted a clinical trial was to result from the data.

I called clinicaltrials.gov and they knew and had nothing about it. Same for PanCan.org. So using the internet, I found contact info on the first author of the paper and called PanCan.org if they would call and make the introduction about my case. They did and that led to being the first enrolled in the trial and going on to have a complete response, achieving NED status 6.5 years ago and recently being declared cured using chemotherapy 10.5 years after having stage IV disease.