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Treatment approaches for MRD positive AML in remission
I’ve recently completed both induction and consolidation chemo (4 cycles) for NPM1 mutated, favorable risk AML A morphological exam of a bone marrow sample showed no signs of lingering AML. I feel great and am back to building up my strength and endurance. However, the MRD using flow cytometry showed an immature myeloid population comprising .028% of all cells.
Since the cutoff for positive versus negative is .01%, I was labeled MRD positive.
I’m not as concerned with the positive versus negative classification, since the numeric values give me more insight into what’s going on. (Perhaps that’s not a good way to look at things?)
I know my oncologist will want to continue monitoring my condition, but I’m wondering if anyone has undergone any sort of treatment, short of a BMT, to eliminate remaining cancer cells.
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Thank you for your post as I had MRD done in July which resulted in no mutations (FLT3 or NPM1)! My Hem/Onc gave me the option to stop treatment however I will continue (weekly blood draws) as my ANC number (WBC, RBC too) has never been in the “normal” range. I am taking this to mean that I still have cancer cells the MRD did not detect…to which my MD concurred.
My AML was diagnosed in March, 2024 and after induction therapy I have been in treatment of varying lengths (7/21 Dacogen Ventclextca to now 1/2).
I elected not to have BMT.
I was diagnosed with Systemic Amyloidosis AL March 2024. @ the Mayo Clinic Rochester. What a ride it has been. Came home and started tx. There were days I thought today’s the day! I’m gonna die. But I’m still here. I did the chemo/ steroids and 2 shots a week for 6 months. My numbers for Light chains were being very cantankerous, they were dropping but not fast enough. According to the new oncologist I got to see in September of ‘24. She changed things up no more chemo/steroids dropped to 1 shot of Darsalex a month, she put me on 400 mg of Venclexta a day. My numbers dropped dramatically. I am happy to say that my numbers are below the ‘normal’ range. I feel good most days. I do have problems with dehydration. But am actively doing better & keeping hydrated, but still is hard at times.
My problem is my blood pressure, it falls low upon standing so I have a wheel chair I call Capt Dan(yes)! I get around pretty good. With help of course- thank the Lord for my husband and family for their help. Sure puts life into prospective when something like this happens to you.
I have never read where someone had or was taking Venclexta. On here. So I thought I’d reach out. & say 👋🏻.
I have to get another BMB before my oncologist will lower the dose of the Venclexta. We talk again on October. Hoping this will happen soon. Maybe the dehydration will not so much a problem.
Thank you listening. Have a great day!
I have aml and take vidaza and venclexta...but I have mutations and hoping to get into remission soon..hoping the best for you .