Testosterone Recovery after stopping orgovyx

In clinical trials, 55% of people on Orgovyx recovered testosterone levels 90 days after a 48-week course of the medication. However, everyone is different and recovery varies depending on certain factors. You might have to wait just a while longer for full recovery.

(I was on a 6-month regimen of Eligard. It took 3 more months - 50% longer than the injections were for - for my testosterone level to return to baseline.)

I had 45 radiation treatments as well as 12 months on orgovyx. My T level was 397 when started and dropped to nearly 0 immediately after the treatments. After 2 tread my T rise to 134 but has since dropped to 108 where it has remained for the past year. My urologist does not want to start TRT until we see what happens in the next 6 months. Not happy with this as low T is a real issue with bring tired all the time. In addition I have now developed peripheral neurapathy in both legs. Have tests showed no never function below the knees. After research I have discovered that the radiation from the 45 treatments may have caused the neurapathy. It is called radiation induced peripheral neuropathy. Finally met with a neurologist who basically said that the radiation treatments could not have caused it. I sent him articles from major studies that show it is real and now he no longer wants me as a patient. Looking for a new neurologist. Any one have these issues.

Wow … so sorry your neurologist does not want you as a patient. That takes arrogance to a new level on his part. I’ve learned to keep my research findings to myself. And just nod when a doctor says this or that. Doctors tend to be inflexible and they like to stay in their own care boxes. I hope you find someone who is open to discussions and is more flexible regarding your care.

I am 89 years old. I just met my Oncologist yesterday. He said it may not go up anymore! He said get another test 6 weeks from now and if it doesn't go up he is open for TRT.

I’m “only” 70y. But at 89y, quality of life would be a primary factor in any decision I made.

If I did TRT, I would do frequent (every 3 months????) PSA tests.

As long as my PSA stayed well below 0.10 ng/mL and my PSADT remained well above 12 months, I’d feel ok with it.

Gosh @golferdto - about 24 total months (i.e., 12 months of Orgovyx plus, if I am reading this correctly, about another year, maybe less, of post-Orgovyx testosterone recovery) and your urologist is still reluctant to let a 108 ng/dL total testosterone (T) level man utilize TRT? Sounds awful and overly cautious to me.

I was on TRT for 13 years after my 2012 low T diagnosis. I stopped T injections as soon as my biopsy confirmed Gleason 4+3 in March 2025. Now two months later my T is so low that I don't need Lupron or Orgovyx androgen deprivation drugs to begin my radiation treatments in early June. And I'm expecting my natural T rebound in future months to be quite small and likely similar to yours. Probably around or near 100 ng/dL. Not enough for a decent quality of life, especially since I need to resume employment.

I'm tentatively planning to resume TRT around month #8 of this self-imposed "castrate level" T. Can't imagine remaining at this level as you have endured for nearly two years.

Hope you are successful in finding a new neurologist. Maybe a new urologist too.

Radiation can cause just about anything - including neuropathy. That neuro doc sounds like a Real A***ole.
If not the radiation, what caused it, huh? If he was in the same health system/hospital it’s a classic case of gaslighting to cover their butt…
Phil