Teriparitide - ugly fatigue & headache. Need ideas, please!

Posted by pjwesty @pjwesty, Apr 13, 2025

Hello! I am about a month in with teriparitide and I want it so much to work for me. I take the injection between 8:30-9:00 AM and around 11:00 or so the headache, fatigue and fog knock me out. I have never been a napper and I sleep solid for 45-60 minutes. When I wake up I am a foggy mess until 4-5 PM. The day is wasted. I plan on reaching out to my endo, but to be honest, he’ll again say, “If it continues, stop taking it and go to the ER”. I’ve read about injecting every other day for a week or two or stopping for a week and starting back. Is that something that works? FYI: I hydrate like crazy, take 1000 Vitamin D and eat plenty of calcium rich foods. Spine -4.2, femoral hips -3.5. Multiple fractures. Thank you so much for any advice you can offer

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Profile picture for gently @gently

The Forteo you've taken has already stimulated cells you need to build bone. You won't lose much in these three to four days plus you'll feel good and that might help your reaction to the next injection. Forteo isn't like the newer medications that start reversal when a few days are missed.

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Thanks for the response. I’ll start again Tuesday or Wednesday. I think the lack of organization at the pharmacy was even more upsetting to me.
What do you mean ‘feel better’ without?

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I had the same reactions. My dr suggested take before bed and I did and symptoms are gone.

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Profile picture for roslynroslyn @roslynroslyn

Thanks for the response. I’ll start again Tuesday or Wednesday. I think the lack of organization at the pharmacy was even more upsetting to me.
What do you mean ‘feel better’ without?

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roslynrosyln,
I was referring to that aforementioned afternoon fatigue. The interlude could distinguish between autoimmune and pharmaceutical effect for you.
We chould be gentle with our bodies giving them a chance to adjust, with a wary eye for any longer-onset symptoms.

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Profile picture for sodita @sodita

Take it at night before going to bed. It helped me !

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I have always taken it at night about 20.00 hrs so cannot compare with taking it at other times of the day but have not had an adverse reaction for 8 months. Good luck.

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Profile picture for gently @gently

roslynrosyln,
I was referring to that aforementioned afternoon fatigue. The interlude could distinguish between autoimmune and pharmaceutical effect for you.
We chould be gentle with our bodies giving them a chance to adjust, with a wary eye for any longer-onset symptoms.

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I think I just lost my long response. All to say I appreciate your response and I would tend to agree since I have many autoimmune issues. MCAS , chronic Lyme and more.
I’ll let you know. (My fatique wasn’t as bad today!)

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I take teriparatide at night after dinner. I lay on the couch and walk around a little to move the calcium around.
I do get some brain fog and fatigue, but I take every other day so it is not horrible. I made my doctor let me get a DEXA after 8 months and my bone density has increased quite a bit, so, I'm going to continue as long as I can take it.

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Profile picture for broken13 @broken13

I am also on Teriparatide and highly recommend you take it at night before bed. I also got headaches the first few months, but luckily I am experienced with migraines and had migraine medication on hand. I am 6 months in now, and no side effects. Headache only if I try drinking wine, which does not seem to go well with the Teriparatide. Darn.

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@broken13
Were your headaches just on one side of your head. Mine are. I haven't had migraines in 20 years, and this has started since the Forteo. I've had recent dental work, so I don't know if that could be the cause.

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Profile picture for marieaw @marieaw

@broken13
Were your headaches just on one side of your head. Mine are. I haven't had migraines in 20 years, and this has started since the Forteo. I've had recent dental work, so I don't know if that could be the cause.

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@marieaw As I recall, they were a bit different than my previous migraines, but the migraine medication did help. Also taking my injection at night before bed with two Tylenol. Drinking lots of water in the day was key. The headaches did subside after the first 3 months or so.

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Profile picture for broken13 @broken13

@marieaw As I recall, they were a bit different than my previous migraines, but the migraine medication did help. Also taking my injection at night before bed with two Tylenol. Drinking lots of water in the day was key. The headaches did subside after the first 3 months or so.

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@broken13
Thank you. I'll keep trying.

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Profile picture for marieaw @marieaw

@broken13
Thank you. I'll keep trying.

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@marieaw Just another thought, was your dental work on the side you feel the headache? I did experience that after a filling that was later discovered to actually be a cracked molar that had not initially showed up in X-ray. Something to check maybe.

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