Tamoxifen and uterine fibroid

Posted by taprep @taprep, Nov 20 9:25pm

Hi All,
I have been recommended to take 20mg Tamoxifen after my radiation. I have uterine fibroids and Tamoxifen can increase the growth of those fibroids. Anyone have been in same situation and how did you deal with it?

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I have been on Tamoxifen for a year if you have other questions I can help you with. In perimenopause I had an endometrial polyp removed but I haven’t had fibroids. Im post menopausal and I’m trying to limit my sugar and fat intake and get enough exercise. I’m really conscious about not putting on weight to try to reduce uterine cancer risk.


@triciaot thanks for your reply. I have 2-3 uterine fibroids. Want to find out if Tamoxifen will increase the size of those fibroids.


According to this study, Tamoxifen is associated with a slightly increased risk of uterine cancer and other changes.

– The effect of tamoxifen on the genital tract https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2482152/
"Tamoxifen results in a spectrum of uterine abnormalities including benign alterations such as endometrial polyps, endometrial hyperplasia, endometrial cystic atrophy, adenomyosis, and uterine fibroid growth as well as malignant transformation into endometrial carcinoma and uterine sarcoma[4–8]."

@taprep, have you discussed your concern with your oncologist? I would inquire about your personal risk factors given that you already have uterine fibroids, whether you are pre or post-menopausal, risk of breast cancer recurrence, etc. What monitoring would be required?


Thanks for your reply…I did discuss with medical oncologist and she said we will start with Tamoxifen and will do ultrasound in an year to see how if it effecting the fibroids , my gynecologist suggested to have uterus removed which I am not much in favor but if required I may have to opt for that.

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