Strontium citrate, fractures and lack of research

Posted by pami @pami, Apr 15, 2024

I am looking to see if there are any studies done that show a reduced chance of fracture from using Strontium citrate (Algaecal) as opposed to calcium. Everything I have read only mentions increase of density using it. Does anyone have doctor input or a study showing an decrease in bone fractures?

***Director's Note:***
There’s not enough clinical research to know if strontium citrate effectively prevents or treats osteoporosis. Mayo Clinic does not recomend its use. Clinically researched osteoporosis medications have demonstrated fracture prevention benefit with less risk.  

The FDA doesn’t regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain.

If you wish to take a strontium supplement, it is advised to discuss with your doctor. 

All information shared by members on the Mayo Clinic Connect is for informational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your health. Never disregard professional medical advice or delay in seeking it because of something you have read on the community.

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Profile picture for drsuefowler @drsuefowler

@kathleen1324,
I have been trying to find a doctor who will prescribe estrogen patches for me, but no luck so far. I have not taken the Raloxifene for fear of blood clots. Although my Endo told me that it was safer than estrogen, I'm not sure that I believe him. Thanks for your suggestions. I will check with the compounding pharmacists in my area for a good hormone specialist.

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@drsuefowler raloxifene doesn't cause breast cancer. Estrogen has that potential. Is that what your doctor meant or were they referring to cardiovascular effects?

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Profile picture for windyshores @windyshores

@drsuefowler raloxifene doesn't cause breast cancer. Estrogen has that potential. Is that what your doctor meant or were they referring to cardiovascular effects?

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We were talking about blood clot risks.

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Profile picture for psmnonna @psmnonna

I'm on month 11 of Tymlos and although I'm having some side effects that are manageable, I'm getting tired of being tired all the time. I started looking into strontium and now I'm very interested in anyone who has had success/experience with this supplement. How much per day? Does it interact with Tymlos or any other supplements for that matter? What is the best way to add it to your diet? I take a daily vitamin, fish oil, K2, D3 and magnesium. I eat enough calcium per day to not take an extra supplement, also exercise, walk, bike, weight training, yoga, pilates. No fractures. Last dexa score was -3.6 in the spine and in the -1s in hips. Based on the spine my endo said Tymlos was the cure all, be all. I am not due for another dexa until Jan 2025 and that will be a full year of Tymlos, so hoping it is doing something. Thanks one and all for your input!

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@jtdesignertbdl which drugs are you referring to that you feel can cause heart attack, stroke or breast cancer? To my knowledge none cause breast cancer or any cancer of any kind. Evenity has a black box warning for cardiovascular risk but in a study comparing it to placebo, there was no difference. When comparing it to alendronate there was a small difference and it is theorized that is because alendronate is slightly protective.

You may have a mild case. For some on this forum the spectre of hip fracture is a lot closer than yours. I hope you can do a consult with Keith McCormick to help with alternatives and if your bones get bad enough, I hope you get accurate information and can get advice from him on meds. Right now I know I have no choice but meds. After 7 spinal fractures I am grateful for them.

I won't get into a debate but if you make statements that medications are dangerous and cause certain diseases, it is helpful if you provide sources.

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I started taking Mykind Organic plant calcium with Vegan D3, K2, Magnesium and noticed it also has 4 mg organic(from organic algae) Strontium per serving.
Is this safe/effective? Bone density went up 5% in one year.

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Profile picture for nene78 @nene78

I started taking Mykind Organic plant calcium with Vegan D3, K2, Magnesium and noticed it also has 4 mg organic(from organic algae) Strontium per serving.
Is this safe/effective? Bone density went up 5% in one year.

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@nenn78 the therapeutic dose of strontium is 680mg daily. That 4mg is probably window dressing! (I am sure you know that an effective dose of strontium will make your DEXA look better than it is.)

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I don’t know about it. I am taking 12 mg/day. Is it true bone mass gain?

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Profile picture for windyshores @windyshores

@nenn78 the therapeutic dose of strontium is 680mg daily. That 4mg is probably window dressing! (I am sure you know that an effective dose of strontium will make your DEXA look better than it is.)

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As I mentioned this is plant based not metal strontium. And I had a 5% increase in bone density in one year taking 16 mg /day

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Profile picture for nene78 @nene78

As I mentioned this is plant based not metal strontium. And I had a 5% increase in bone density in one year taking 16 mg /day

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Strontium is an element and is classified as a metal. Strontium Citrate is synthesized from Strontium (whether harvested from plant, animal or the earth) and Calcium Citrate. The supplement mentioned by @windyshores contains 6mg of strontium.

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Yes, actually there are several studies done that show a reduced chance of fracture from using Strontium via citrate and strontium via ranelate, indeed any strontium. If you are only interested in Algaecal with strontium then you might contact Algaecal but their strontium is the same as all other strontium in the bone building and fracture prevention category.
It is important to understand that strontium is the bone building component in any strontium product; so if we are talking about bone health then any strontium research may be evaluated for fracture etc. information ie strontium via ranelate or strontium via citrate. If you are considering side effects then other additives even those considered inactive need to be evaluated. Ex the ranelate and aspartame in strontium via ranelate.
But you are asking about bone building and fracture prevention so you may evaluate using any strontium research.
The current research shows a reduction of 41% to 49% in fractures. (link to research and posting below) The compilation of research done on all strontium has surmised that the reduction of fractures is possibly due to a formation of something called sacrifical bonds which make strontium bone more impervious to fracture. ( See links below)
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/2020-a-review-of-latest-insights-into-the-mechanism-of-action-by-strontium-/
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/strontium-does-it-prevent-fractures-research-articles-personal-stories/

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Profile picture for windyshores @windyshores

@nenn78 the therapeutic dose of strontium is 680mg daily. That 4mg is probably window dressing! (I am sure you know that an effective dose of strontium will make your DEXA look better than it is.)

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Yes, the dexa reading for a bone with strontium is considered to be over read by about 10% due to the way strontium affects the radiation used in the dexa analysis. But we no longer have to depend on DEXA; REMS and TBS both are not affected by the strontium radiation overread of DEXA. Interestingly, a TBS study of bone quality found strontium bones to be in the top 3 of treatments for bone quality. But even if you depend on DEXA it is only the first reading on strontium treatment that is pertinent for what is called the 10% strontium skew, after that you are just cking to make sure that your bone density continues to increase.
So this "oh no the dexa misreads strontium what will we do" scenario is no longer relevant. We now have REMS and TBS, and both those bone tests all say that strontium bone is dense and good quality bone. Plus, we have a research study with bone biopsies of strontium bone and viola good bone density and good bone quality. Amazing what mother nature has wrought with calcium and strontium in our water and ground.
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/tbs-dexa-and-strontium/reply/7712668597918129698/
https://onlinelibrary.wiley.com/doi/full/10.1359/jbmr.071012

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