What causes stroma and/or fibroblast around pancreatic cancer cells?

Posted by wheatley @wheatley, Nov 30, 2023

What causes stroma and/or fibroblast(?) around pancreatic cancer cells? My scans show soft stringy tissue around several blood arteries/veins causing vessel “encasement and obliteration”. Sounds like the stroma, etc protects cancer cells from effective treatment. Any thoughts?

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Peter S (Aussie) | @spicerpa | Dec 1, 2023

I have read similar information. It appears that this can prevent / reduce the effectiveness of chemo in some patients.

I also understand that lots of research and drug development is focussed in addressing this specific issue. Ie break down the stroma / fibrosis then do chemo