Is there anything to help stop or slow progression of MGUS?

That sounds encouraging. Do you do anything special like supplements, etc.

Just saw my Oncologist on Friday, October 4th, my blood work looked good. I am 67-year-old male. My M-protein spike has been consistently between .5 and .7 for 18 months, it was .6 at this visit. My free Kapa light chains has been high, progressed from 37.6 in May of 2023 to 45.0 this visit. My Oncologist moved me from every 6 months follow-up to nine months, which was encouraging. The best thing you can do with MGUS is just to have it monitored. With a 1% per year progression rate, I feel my odds are good.

Thank you so much. Could you tell me the name of the tumeric you use please. I just have regular tumeric capsules from Costco

I am 70 and my MGUS started 8 years ago. There is a lot of research now on designer proteins that can lock onto the nasty-bits mutated cells in the bone marrow and stop replication, but those are generally just used in late-stage SMM (smoldering multiple myeloma) or MM. They are not used in MGUS due to side effects, and for most people with MGUS, it doesn't progress to SMM or MM. So, the longer one can go with just MGUS the closer to better treatments. ResearchGate has a lot of good peer-reviewed papers on MGUS, SMM, and MM. A lot of the slowing progression is the same with all syndromes and diseases, take care of yourself, exercise, manage stress, and healthy diet. Keep a food journal in case you have any food intolerances that might cause inflammation or other issues. Some people take bioavailable curcumin. Curcumin is in turmeric root and has been found to decrease TNF (tumor necrosis factor) in high doses (higher than just adding turmeric to stuff). Curcumin is poorly absorbed by the GI tract so supplements\ with peperine (from black pepper) or lipids (fats) and eaten with food help. There are a lot of brands, just make sure it is bioavailable rather than just curcumin or turmeric. I take about a gram/day of curcumin but most of the research is on 4-7 gm/day. It can cause side effects for some and does thin the blood a bit, so check with a doctor before ramping up.