Is there anything to help stop or slow progression of MGUS?

@amyboylan1
I also have a ratio

FWIW this is results from my BMB. Let me know if this is pretty standard or not.

So I went to see the overflow Hematologist. He had to get permission from the boss to find out if he could share my BMB with me. He did tell me my infiltration was 20%. I told him my regular Hematologist had agreed that awmrisk.com calculator was probably good because it's put out by Dana-Farber. So he agreed and plugged in the numbers exactly as reported from the lab and pronounced my as medium risk. I pointed out to him the reference values from the lab are different than what the calculator uses and must be adjusted for. The lab even mentioned that in the fine print. He claimed as long as the units are the same reference numbers don't matter. We argued over this and he wouldn't budge nor would he explain why I was wrong. I then asked him what he would do to slow the progression. He mentioned different chemo and monoclonal antibodies but told me he couldn't recommend a treatment because he was just a stand in. I asked if there was any benefits to taking Curcumin or having a lower BMI. He asked if I wanted body parts cut off. I replied no, I want to grow 3" taller. When I got home, I plugged in my higher adjusted numbers and my risk actually went to low. Go figure! I think I have 50% chance of going 9.3 years rather than the 4.8 years he gave me. I then asked him what he would

Thanks for the tip @natelew Not having pain or tingling YET, but will keep it in mind. I did use a very cold pool dip to numb a real bad case of poison ivy once.
A month ago I asked for all the tests be done to fill out the awmrisk.com calculator. I had all the tests done and adjusted the results for lab reference differences. The only piece of the puzzle still missing is the bone marrow %. Today, I was told the results are in but they aren't going to show them to me until tomorrow when a Hematology/Oncology Dr will discuss them with me. This has me very puzzled as I have had many labs done over the 50 years I have been with this medical insurance company and they have never withheld any results like this before. I'll post here when I know more.

Not sure if this would help but if you can get in a pool it sure does help with pain and tingling.

Good morning 1oldsoul. I expect my BMB results will come out very soon. I'll let you know. The big difference between us is my M-spike & IgM are 3X higher than yours. Last November, I got serious and watched my diet closely and took massive amounts of Curcumin. My March labs showed the progression had slowed by 7X. I then went on a two week cruise that unexpectedly turned into 5 weeks. I ran out of meds & stopped taking the Curcumin. My latest labs are terrible.
Based on a study, I'm now trying to lose weight below 2.5 BMI in addition to all other strategies of Curcumin and keeping my glucose levels low. I now only eat twice a day at 10am and 5pm. There is a study for a plant based diet. I may also go there.
BTW, this was my first BMB and I was a little nervous. I didn't have a driver so I elected to just having a local. She took four tubes of marrow and a chunk of bone. I only felt slight pressure.
My biggest concern now is another cruise in two weeks that was booked months ago.

DanaFarber has been conducting clinical trials using plant based diets. There are also MGUS clinical trials using Metaformin.
Thirdly, a normal BMI has been shown to be protective.
I was first diagnosed with MGUS in 2002 - 23 years ago. It has largely been stable except after major surgeries. My MGUS showed up
after surgery for a ruptured appendix and sepsis - was in the hospital for 2 weeks. I also had four joint replacement surgeries after which my free light chains increased. Three were under regional anesthesia and the last (a shoulder) had to be under general anesthesia.
I tried Metformin but could not tolerate it. If you go that route, I suggest using the extended release version. I heard about that belatedly but am now actually terrified of the drug.

@dcuste
Good morning. Please keep us updated with your BMB results. I have also had IGM Lambda for 4 years and although my light chains, CBC and complete metabolic panel are normal, my IGM continues to climb 100 points a year and is now in the 700+ range. Just had a viscosity blood test last Monday (checking paraproteinanemia) and it was also normal. My most recent IGG was normal but IGA and IGG have been low since diagnosis. The hematologist didn’t seemed very concerned a year ago and said my numbers were much better than most of his patients. When I mentioned last Monday that his other patients had IGM in the thousands, he said “yes, and that’s when it’s scary” Unfortunately I am unable to tolerate high doses of Qunol Turmeric/Curcumin. I get very weak and tired and the only thing I can think of is I am borderline anemic and it is blocking absorption of iron, even taking it away from an iron supplement. We are in the process of moving to the Corpus Christi area in Texas to be closer to family and when I get settled I am going to find a naturopathic oncologist and see what can be tried.

@amberl99 That’s the exact response of my hem/onc doc when I asked him.
My numbers went down for a year and a half, then I had major surgery and a subsequent fall. Numbers went up. I am about to go back in a few weeks. Hopefully it was just surgery, fall trauma.
I hope your experiment is successful. Do you mind letting me know?

H what was your father in law treated with? How many treatments and sany serious side effects?