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Stopping Nubeqa and Orgovyx after 6 months

Posted by glabelle @glabelle, Aug 31, 2025

Diagnosed with stage 4 PC. Single 4+4 lesion on prostate, two others at 4+3. PET showed small spot on my pelvis and even smaller one on a single lymph node in my pelvic area. PSA 17.
Started ADT 5 months ago and had MRidian SBRT 4 months ago (5 consecutive days).
My PSA has been < .04 for past three months.
Follow up PET showed spot on pelvis and lymph node fully resolved.
When I started on ADT, oncologist told me that he thought 6 months of ADT might be adequate. As most of you guys can attest, ADT is no fun.
I’m worried that my oncologist will tell me that another 6-months would be ideal.
Anyone out there with a similar diagnosis that has only been on ADT for 6 months. If so, how did things work out?

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

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glabelle | @glabelle | Apr 3 9:26am
In reply to @jeffmarc "@glabelle If somebody is a Gleason seven then Stopping ADT after six months is reasonable. If..." + (show)
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@glabelle
If somebody is a Gleason seven then Stopping ADT after six months is reasonable. If a Gleason eight even NCCN recommends 12 months of ADT.

Besides the Gleason score, you’ve also had metastasis in other spots. Were those spots zapped with SBRT when you had your radiation treatment, Or were they just controlled by ADT? That can make your cancer a lot more aggressive. What’s your doctor think about this? I’m pretty sure most genito urinary oncologists Would recommend 12 months of undetectable PSA before stopping. Has yours remained at < .04 since August?

If you want to get another opinion, come to the ancan.org Weekly advanced prostate cancer meeting next Week on Monday at 8 PM Eastern time. Go to the website and if you sign up, you’ll get a newsletter every week that has some really great stuff in it about the latest treatments in prostate cancer. The guys that run, the meeting have 15 years experience, helping people with their prostate cancer treatment. There’s almost always three or more doctors in the room. You need to install GoTo Meeting on your device, it works on any computer phone or tablet and it’s free. You don’t have to sign up to go to the meeting. You will get advice and information there that nobody else has given you.

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@jeffmarc such great information. Thank you! I will be there!

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