1. < Prostate Cancer

Stage 4 metastatic prostate cancer

Posted by majed @majed, 1 day ago

Hi all
My husband was diagnised with stage 4 metastatic prostate cancer, it has spread to bones and nearby lymph nodes, he is 51 and with other health issues
Whatbis his prognosis please

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majed | @majed | 16 hours ago
In reply to @northoftheborder "Stage 4 to my spine in 2021 at age 56. I'm still here, still going strong,..." + (show)
@northoftheborder

Stage 4 to my spine in 2021 at age 56. I'm still here, still going strong, and still in full medically-induced remission.

Everyone's experience will be different, but especially if the stage 4 cancer is "oligometastatic" (just a few metastases) and "castrate-sensitive" (responds to hormone therapy), the prognosis could potentially be good, especially if he's getting modern treatments like radiation to his prostate and metastases, and one of the second generation ARSIs (the -lutamides) as part of his hormone therapy. More here:
https://www.scientificamerican.com/article/treating-prostate-cancer-at-any-stage/

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How long will he stay hormobe sensitive?

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northoftheborder | @northoftheborder | 13 hours ago
In reply to @majed "How long will he stay hormobe sensitive?" + (show)
@majed

How long will he stay hormobe sensitive?

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It's different for everyone, unfortunately. Some people go many years without developing castrate resistance, and some only a few months. As I mentioned earlier, taking a second-generation ARSI (one of the "-lutamides") together with ADT can significantly extend castrate sensitivity for many patients, as it has for me so far.

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northoftheborder | @northoftheborder | 13 hours ago
In reply to @northoftheborder "It's different for everyone, unfortunately. Some people go many years without developing castrate resistance, and some..." + (show)
@northoftheborder

It's different for everyone, unfortunately. Some people go many years without developing castrate resistance, and some only a few months. As I mentioned earlier, taking a second-generation ARSI (one of the "-lutamides") together with ADT can significantly extend castrate sensitivity for many patients, as it has for me so far.

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They initially told me I'd develop castrate resistance in 18–24 months, because that was still the received wisdom in 2021. Obviously, that time scale was wrong, since it hasn't happened yet in 2025 (thanks in part to Apalutamide, which seems like a game changer).

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