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Has anyone had Signatera testing (genetics-based cancer test)?
I'm wondering if anyone here has heard of or had Signaterra testing? I just learned about it from a neighbor who works for the company that developed it. I have Stage 3b ovarian cancer and apparently that's one of the indications for having the testing done. It sounds like a good thing to do but I've never heard about it before and that makes me wonder....
Thanks for any information!
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@ginmav Not really. I have occasional tiredness but blame that on having to get up early for an appointment. No GI issues. I Do have some joint discomfort from time to time. Other than that I feel great!
@jandrew1922
Are you experiencing any side effects.
@jandrew1922
That's wonderful.
I take 600 of lynparza and feel tired a lot. I was always very active but now I do what I can. Most frustrating for me.
Have you been on this drug very long?
I have Signatera testing every three weeks, as part of a clinical trial for treatment of residual disease from primary peritoneal cancer, originally graded stage 3C. This cancer is generally treated the same as ovarian cancer. My doctor is not sure what the test results mean as of yet, but does testing in conjunction with scans and CA125. I think it’s appropriate only if you are NED or have microscopic disease, as opposed to visible tumors. It tracks a small amount of circulating disease in your blood or the lack thereof. Natera has a website where you can track your results (very helpful) and they offer counseling on the results. Just another tool in our arsenal.
@carol1024
Carol, I look forward to hearing what your doctor says about this. Also, are you willing to share what type of EC you have and the treatment plan? I was Stage 2 , Grade 3 clear cell with no significant markers. I had a recurrence while getting chemo so I’m chemo-resistant, and I also had external beam radiation and brachytherapy. Currently NED.
@ffr I was stage 3 when I had first PET in March. I had 4 months of chemo and immunotherapy. After the hysterectomy and pathology report I was stage 4 but my doctor told my daughter I was stage 4 after the ssurgery. I am now on Herceptin because of the HER2+ and will have 3 treatments then another scan. There is active disease left after the surgery and we're just hoping this round of chemo knocks it all out. 🙏🏻🙏🏻
Thank you for sharing.
I am hoping that this works for you! Not fun, but we try everything at our disposal because we choose life.
🤗
@ginmav I started Lynparza in February of 2025. Prior to that was on Zejula but my platelets and blood count dropped badly so I had to stop it and get a platelet transfusion.
It is a game changer. I had a lymph node recurrence that was picked up on the Signatera test with a CA 125 at 7. Had I not insisted on having this test it would not have been picked up for 3 months when I had my next scans scheduled. As it turned out I had robotic surgery to remove the node as well as 4 others removed for biopsy but only one was bad. I still had to go through chemo but hopefully only 3 rounds as my Signatera is now negative for two months. I will continue get the Signatera monthly as CA 125 is useless for me. Hope this helps you and everyone else reading to make sure you advocate for this test. I am on medicare so it is covered for me.
Rainy Seifer
Napa CA
@carol1024 Will you please let me know how your doctor interprets and uses the the Signatera Test for treatment planning for you? I looked at your results that you shared (thank you) and I'm not sure what the metrics (numbers on the graph) mean.
Thanks.