Signatera Test. Is it truly helpful and worthwhile?

I would say Signatera test is a valuable tool. I was diagnosed with stage 2c high grade serous endometrial cancer with abnormal p53 in April 2025. Following surgery, I started chemo which I could not tolerate due to it causing severe neuropathy, heart issues, and high blood pressure. My oncologist hematologist recommended the test. I just had a low positive result after 2 negative test results and am scheduled for a PET scan.
I feel the tests are extremely important and can help guide treatment choices for patients like me that cannot tolerate chemo. They also can help determine if treatment is working. There are some oncologists that are not on board with the tumor-specific testing yet. They seem to be more concerned that there is not enough research behind it. However, there is new evidence coming out that validates the accuracy and value of this type of testing as it tailors treatment to the patient. Unfortunately, Cancer treatment “cookie-cutter” approaches (6 rounds of chemo, etc) for every patient needs to be revisited. Each one of us is different and our treatment plan should be focused on what works for each patient. My opinion, of course.

To lifetraveler: Many thanks for this information. I'm glad I changed Med Onco as well! BTW, a different Med Onco told me that it's unclear if/how to change treatments plan based on results of Signatera. I think that's because circulating tumor DNA doesn't necessarily mean the existence of a solid tumor. Do you know anything more about this?

Also a question: are the blood tests for tumor markers covered by Medicare? So far, my Med Onco hasn't ordered any.
Many thanks in advance! Peg