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What experience has anyone had with the Signatera blood test?

Posted by babab @babab, Aug 19, 2024

What experience has anyone had with the Signatera blood test. My results have been 0.13, 0.15, and now 0.17.

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jaxfl | @jaxfl | Sep 27 7:37am

The signatera order does not show up on the natera patient portal and so far I have not received the usual confirmation email/text by natera that they received the sample. I asked the RN yesterday and she stated she was adding the order. So this could be another example of Mayo disorganization. It is very frustrating I keep running into these issues.

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jaxfl | @jaxfl | Sep 26 1:28pm
In reply to @jaxfl "Rash is down significantly. As is the itching. Bloodwork today showed my eosinophils skyrocketed to 0.69..." + (show)
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Rash is down significantly. As is the itching. Bloodwork today showed my eosinophils skyrocketed to 0.69 and 13%. Also an unexpected signatera draw.

@141emp: I am losing pigment in tiny spots on my arms and legs.

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Interesting video: https://m.youtube.com/watch.

Interesting reading: https://pmc.ncbi.nlm.nih.gov/articles/PMC7153834.

Nivo seven was uneventful this morning.
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jaxfl | @jaxfl | Sep 25 11:17am

Rash is down significantly. As is the itching. Bloodwork today showed my eosinophils skyrocketed to 0.69 and 13%. Also an unexpected signatera draw.

@141emp: I am losing pigment in tiny spots on my arms and legs.

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141emp | @141emp | Sep 24 2:04pm
In reply to @jaxfl "I can imagine. The rash is moving all over my body. Plus I have some tiny..." + (show)
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I can imagine. The rash is moving all over my body. Plus I have some tiny weird loss of pigmentation in some spots now.

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@jaxfl my reactions have been pretty consistent from cycle to cycle. Sounds like the skin reactions are different for everyone I know on this. I look sunburned and have an eczema type rash in many places, some people don’t have any , some lose pigment. It’s not fun, that’s for sure but I’m grateful it seems to be working. Wish you the best!

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ronzee50 | @ronzee50 | Sep 24 12:54pm
In reply to @141emp "Natera has amazing technology but very poor operations and customer service in my early experience. I..." + (show)
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Natera has amazing technology but very poor operations and customer service in my early experience. I almost refused to use them until my new surgeon personally assured me everything would be handled his office. He didn’t let me down. There were no problems.

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My second test went smoothly. Naturally requested another blood sample before I received the results from the first test. I had my blood draw at home. Everything progressed as it should have. There were notifications of the receipt of the blood sample, an estimate of when the results would be ready, and notification given of the results. I did not have to contact anyone this time.

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fos | @foss | Sep 24 12:53pm
In reply to @ronzee50 "So far, not a good experience with Natera. It started off fine. Mayo sent the tissue..." + (show)
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So far, not a good experience with Natera. It started off fine. Mayo sent the tissue and showed received on my portal within two days. Within a week, my portal said tissue needed. I found out that they sent the request to my previous urologist who did my TURBT last year. It’s been three weeks and they are still waiting. So, I’m presuming they are not going to get the tissue they need to perform the test. I had my oncologist office try to follow up with the urologist office. I figured it would be more important coming from another doctor. Until a tumor returns, I won’t be able to do the Signatera test.

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Tried them all. Found Coloplast the best. Been using that product for several years now. No problems. Foss

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jaxfl | @jaxfl | Sep 23 3:28pm

I can imagine. The rash is moving all over my body. Plus I have some tiny weird loss of pigmentation in some spots now.

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141emp | @141emp | Sep 23 11:25am
In reply to @jaxfl "Yes. I am also using triamcinoline acetonide cream usp 0.1%. The rash is now almost gone..." + (show)
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Yes. I am also using triamcinoline acetonide cream usp 0.1%. The rash is now almost gone from the chest and back but more noticeable on the sides.

Hang in there! Is your oncologist considering deescalating to just pembro after six EVP cycles? That appears likely based on your commentary.

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I won’t know until after next pet scan and Signatera mid October. My side effects are tolerable for the time being although I struggle the most with eating. I’m eating a lot less than I was before treatment which is not necessarily a bad thing and still get hungry. There is very little that tastes anything like it should. Tough for a foodie that loved to cook.

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jowilliams1 | @jowilliams1 | Sep 17 7:50pm
In reply to @jaxfl "The rash escalated to my sides, chest and back. I received a topical steroid. It is..." + (show)
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The rash escalated to my sides, chest and back. I received a topical steroid. It is receding. Very uncomfortable. The PA does concur it is encouraging from an efficacy perspective.

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Oh that sounds uncomfortable!

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