What experience has anyone had with the Signatera blood test?

First Opdivo around 930AM. No side effects so far. Fatigue but I had to get up at 5AM and I never sleep well when I know I have to get up early.

Both RX’ are to manage nausea when applicable. I still have a lot of OD so I canceled that one.

My bloodwork this morning included Northstar but not Signatera interestingly. I guess my oncologist is looking for a post chemo/pre immunotherapy baseline.

Opdivo at 8AM.

Second generation H1 antihistamines are recommended. So Claritin it is. The oncology RN stated there are no contraindications for Zyrtec and Benadryl. I will drop Zyrtec (seasonal allergies) and add a daily Claritin. The urostomy RN recommended Benadryl against stoma site rash. The oncologist also prescribed odansetron and something else. I am awaiting an explanation.

My first Opdivo treatment will be this Thursday 4/3. I have to figure out which antihistamine to take as research indicates H1 antihistamines boosts efficacy.

We will start nivolumab as soon as my insurance approves the authorization. That can take up to 15 days.

Initially, he suggested monitoring. He called me back around 7PM and agreed to immunotherapy.

He stated northstar is concerning but the significance is uncertain. We have yet to establish a trend. We will complete northstar and signatera again in April and ct/MRI in May.

My kidneys are recovering well after ddmvac 4. No two additional cycles my oncologist told me.

@jaxfl thank you for the continued updates! What came out of your meeting today with your oncologist?

This morning the two tests were not included with my kidney bloodwork. Wait and see what my oncologist is planning observation/treatment wise when I meet with him in 90 minutes.

I was able to get an appointment next week after all. A kind nurse called me to confirm earlier.

There is a significant difference in that opdivo is not combined with padcev like keytruda.

My oncologist is OOO this week (FL spring break). So far I have been unable to make an appointment for next week. Scheduling has availability in May. Obviously, I cannot wait that long nor is that clinically sound. I frequently run into bureaucracy at Mayo unfortunately. Departments are very siloed and the staff not always very emphatic.

This is very interesting. My oncologist (as well as another seen to see if I would qualify for a clinical trial) both agreed that Opdivo and Keytruda are like Coke and Pepsi. Not much difference. I had to go with Opdivo due to my insurance. I started it on 12/30 and the plan is to do 1 year. I was T3N1M0. I like to say was like I'm done. LOL My only real side effect has been the recent shutdown of my thyroid. I'm on medication for that now. I have my second Natera test and another CT this week. My doctors seem to be holding their breath a bit.