What experience has anyone had with the Signatera blood test?

I’ve had several Signatera tests over the past two years. All came back clean - no cancer DNA in my blood. I also have regular cystoscopies and CT scans with contrast. All are likewise clear. As long as these results continue, my doctors will continue to monitor me and consider me cancer free.

I have had great success. It identified that my cancer had returned before it showed up in the scans. I get it done every 6 weeks.

Front door cytology was clear. Stoma cytology was atypical but great news according to resident.

Lost 25LBS since 2025-12 due to loss of appetite. Nivo side effect.

Monocytes dropped off the cliff.

Had to bloodwork a second time. They forgot to put in signatera.

Nivo #11 in progress.

Update. I had nivo #10 on 2025-12-19. On 2025-12-18 I had a CT (clean) and MRI. The MRI noted one right distal external iliac node that had grown 6mm. Plus urostomy inflammation + edema. This scared me of course. The radiologist was measured. She noted no aberrant features (borders, fatty center and such). She only stated: 1) correlate with marker (signatera) and 2) inspect urostomy for inflammation (I had a nasty spot that is resolving). Today, after yesterday's biopsy, it was ruled benign and inflammatory. I was very fearful of recurrence so this is a huge relief. No signatera 2025-12-18 which is odd. Hopefully again this month. Wash (cytology) and clean catch + appointment with surgeon MD this Thursday.

@neurodoc , I'm not sure if you saw the question from @jaxfl. Did you have treatment for bladder cancer? How often are you tested?

Did you have any treatment to end up with six consecutive clear tests?

@colleenyoung First one was 8.2 2 yrs ago now o for last six tests

Welcome, @neurodoc. Did you have the Signatera test and found you had bladder cancer? How are you doing now?

#9 was negative. Praise the Lord!

Thanks! Celebrated by going on domestic vacation last week. Fun but the walking was very difficult. Still waiting on #9 results. Probably delayed by Thanksgiving.